Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles

Khalid E Alzahrani,1,2 Abdurahman A Niazy,3 Abdullah M Alswieleh,4 Rizwan Wahab,5 Ahmed M El-Toni,2 Hamdan S Alghamdi3 1Department of Physics and Astronomy, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Kingdom of S...

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Autores principales:	Alzahrani KE, Niazy AA, Alswieleh AM, Wahab R, El-Toni AM, Alghamdi HS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	nanotechnology antibacterial agents nanoparticles trimetal nanoparticles Escherichia coli Enterococcus faecalis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9ce032204ea5413bb5eddd024cebc3d0
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spelling	oai:doaj.org-article:9ce032204ea5413bb5eddd024cebc3d02021-12-02T01:11:29ZAntibacterial activity of trimetal (CuZnFe) oxide nanoparticles1178-2013https://doaj.org/article/9ce032204ea5413bb5eddd024cebc3d02017-12-01T00:00:00Zhttps://www.dovepress.com/antibacterial-activity-of-trimetal-cuznfe-oxide-nanoparticles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Khalid E Alzahrani,1,2 Abdurahman A Niazy,3 Abdullah M Alswieleh,4 Rizwan Wahab,5 Ahmed M El-Toni,2 Hamdan S Alghamdi3 1Department of Physics and Astronomy, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3Prince Naif Health Research Center, Molecular and Cell Biology Laboratory, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia; 4Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 5Department of Zoology, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia Background: The increasing resistance of pathogenic bacteria to antibiotics is a challenging worldwide health problem that has led to the search for new and more efficient antibacterial agents. Nanotechnology has proven to be an effective tool for the fight against bacteria. Methods: In this paper, we present the synthesis and traits of trimetal (CuZnFe) oxide nanoparticles (NPs) using X-ray diffraction, high-resolution transmission electron microscopy, and energy dispersive x-ray spectroscopy. We evaluated the antibacterial activity of these NPs against gram-negative Escherichia coli and gram-positive Enterococcus faecalis and then compared it to that of their pure single-metal oxide components CuO and ZnO. Results: Our study showed that the antibacterial activity of the trimetal oxide NPs was greater against E. coli than against E. faecalis. Overall, the antimicrobial effect of trimetal NPs is between those of pure ZnO and CuO nanoparticles, which may mean that their cytotoxicity is also between that of pure ZnO and CuO NPs, making them potential antibiotics. However, the cytotoxicity of trimetal NPs to mammalian cells needs to be verified. Conclusion: The combination of three metal oxide NPs (ZnO, CuO, and Fe2O3) in one multimetal (CuZnFe) oxide NPs will enhance the therapeutic strategy against a wide range of microbial infections. Bacteria are unlikely to develop resistance against this new NP because bacteria must go through a series of mutations to become resistant to the trimetal oxide NP. Therefore, this NP can combat existing and emerging bacterial infections. Keywords: nanotechnology, antibacterial agents, nanoparticles, trimetal nanoparticles, Escherichia coli, Enterococcus faecalisAlzahrani KENiazy AAAlswieleh AMWahab REl-Toni AMAlghamdi HSDove Medical Pressarticlenanotechnologyantibacterial agentsnanoparticlestrimetal nanoparticlesEscherichia coliEnterococcus faecalisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 77-87 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanotechnology antibacterial agents nanoparticles trimetal nanoparticles Escherichia coli Enterococcus faecalis Medicine (General) R5-920
spellingShingle	nanotechnology antibacterial agents nanoparticles trimetal nanoparticles Escherichia coli Enterococcus faecalis Medicine (General) R5-920 Alzahrani KE Niazy AA Alswieleh AM Wahab R El-Toni AM Alghamdi HS Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles
description	Khalid E Alzahrani,1,2 Abdurahman A Niazy,3 Abdullah M Alswieleh,4 Rizwan Wahab,5 Ahmed M El-Toni,2 Hamdan S Alghamdi3 1Department of Physics and Astronomy, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3Prince Naif Health Research Center, Molecular and Cell Biology Laboratory, College of Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia; 4Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 5Department of Zoology, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia Background: The increasing resistance of pathogenic bacteria to antibiotics is a challenging worldwide health problem that has led to the search for new and more efficient antibacterial agents. Nanotechnology has proven to be an effective tool for the fight against bacteria. Methods: In this paper, we present the synthesis and traits of trimetal (CuZnFe) oxide nanoparticles (NPs) using X-ray diffraction, high-resolution transmission electron microscopy, and energy dispersive x-ray spectroscopy. We evaluated the antibacterial activity of these NPs against gram-negative Escherichia coli and gram-positive Enterococcus faecalis and then compared it to that of their pure single-metal oxide components CuO and ZnO. Results: Our study showed that the antibacterial activity of the trimetal oxide NPs was greater against E. coli than against E. faecalis. Overall, the antimicrobial effect of trimetal NPs is between those of pure ZnO and CuO nanoparticles, which may mean that their cytotoxicity is also between that of pure ZnO and CuO NPs, making them potential antibiotics. However, the cytotoxicity of trimetal NPs to mammalian cells needs to be verified. Conclusion: The combination of three metal oxide NPs (ZnO, CuO, and Fe2O3) in one multimetal (CuZnFe) oxide NPs will enhance the therapeutic strategy against a wide range of microbial infections. Bacteria are unlikely to develop resistance against this new NP because bacteria must go through a series of mutations to become resistant to the trimetal oxide NP. Therefore, this NP can combat existing and emerging bacterial infections. Keywords: nanotechnology, antibacterial agents, nanoparticles, trimetal nanoparticles, Escherichia coli, Enterococcus faecalis
format	article
author	Alzahrani KE Niazy AA Alswieleh AM Wahab R El-Toni AM Alghamdi HS
author_facet	Alzahrani KE Niazy AA Alswieleh AM Wahab R El-Toni AM Alghamdi HS
author_sort	Alzahrani KE
title	Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles
title_short	Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles
title_full	Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles
title_fullStr	Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles
title_full_unstemmed	Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles
title_sort	antibacterial activity of trimetal (cuznfe) oxide nanoparticles
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9ce032204ea5413bb5eddd024cebc3d0
work_keys_str_mv	AT alzahranike antibacterialactivityoftrimetalcuznfeoxidenanoparticles AT niazyaa antibacterialactivityoftrimetalcuznfeoxidenanoparticles AT alswieleham antibacterialactivityoftrimetalcuznfeoxidenanoparticles AT wahabr antibacterialactivityoftrimetalcuznfeoxidenanoparticles AT eltoniam antibacterialactivityoftrimetalcuznfeoxidenanoparticles AT alghamdihs antibacterialactivityoftrimetalcuznfeoxidenanoparticles
_version_	1718403274793549824

Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles

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