Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells

Currently, there is no effective therapy against lung cancer due to the development of resistance. Resistance contributes to disease progression, recurrence, and mortality. The presence of so-called cancer stem cells could explain the ineffectiveness of conventional treatment, and the development of...

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Autores principales:	Hussein Hamad, Birgitte Brinkmann Olsen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lung cancer cancer stem cells cannabidiol reactive oxygen species apoptosis Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/9ce057d62cca42dcbd7f48daa0063d92
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spelling	oai:doaj.org-article:9ce057d62cca42dcbd7f48daa0063d922021-11-25T18:39:53ZCannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells10.3390/ph141111691424-8247https://doaj.org/article/9ce057d62cca42dcbd7f48daa0063d922021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1169https://doaj.org/toc/1424-8247Currently, there is no effective therapy against lung cancer due to the development of resistance. Resistance contributes to disease progression, recurrence, and mortality. The presence of so-called cancer stem cells could explain the ineffectiveness of conventional treatment, and the development of successful cancer treatment depends on the targeting also of cancer stem cells. Cannabidiol (CBD) is a cannabinoid with anti-tumor properties. However, the effects on cancer stem cells are not well understood. The effects of CBD were evaluated in spheres enriched in lung cancer stem cells and adherent lung cancer cells. We found that CBD decreased viability and induced cell death in both cell populations. Furthermore, we found that CBD activated the effector caspases 3/7, increased the expression of pro-apoptotic proteins, increased the levels of reactive oxygen species, as well as a leading to a loss of mitochondrial membrane potential in both populations. We also found that CBD decreased self-renewal, a hallmark of cancer stem cells. Overall, our results suggest that CBD is effective against the otherwise treatment-resistant cancer stem cells and joins a growing list of compounds effective against cancer stem cells. The effects and mechanisms of CBD in cancer stem cells should be further explored to find their Achilles heel.Hussein HamadBirgitte Brinkmann OlsenMDPI AGarticlelung cancercancer stem cellscannabidiolreactive oxygen speciesapoptosisMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1169, p 1169 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer cancer stem cells cannabidiol reactive oxygen species apoptosis Medicine R Pharmacy and materia medica RS1-441
spellingShingle	lung cancer cancer stem cells cannabidiol reactive oxygen species apoptosis Medicine R Pharmacy and materia medica RS1-441 Hussein Hamad Birgitte Brinkmann Olsen Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells
description	Currently, there is no effective therapy against lung cancer due to the development of resistance. Resistance contributes to disease progression, recurrence, and mortality. The presence of so-called cancer stem cells could explain the ineffectiveness of conventional treatment, and the development of successful cancer treatment depends on the targeting also of cancer stem cells. Cannabidiol (CBD) is a cannabinoid with anti-tumor properties. However, the effects on cancer stem cells are not well understood. The effects of CBD were evaluated in spheres enriched in lung cancer stem cells and adherent lung cancer cells. We found that CBD decreased viability and induced cell death in both cell populations. Furthermore, we found that CBD activated the effector caspases 3/7, increased the expression of pro-apoptotic proteins, increased the levels of reactive oxygen species, as well as a leading to a loss of mitochondrial membrane potential in both populations. We also found that CBD decreased self-renewal, a hallmark of cancer stem cells. Overall, our results suggest that CBD is effective against the otherwise treatment-resistant cancer stem cells and joins a growing list of compounds effective against cancer stem cells. The effects and mechanisms of CBD in cancer stem cells should be further explored to find their Achilles heel.
format	article
author	Hussein Hamad Birgitte Brinkmann Olsen
author_facet	Hussein Hamad Birgitte Brinkmann Olsen
author_sort	Hussein Hamad
title	Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells
title_short	Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells
title_full	Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells
title_fullStr	Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells
title_full_unstemmed	Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells
title_sort	cannabidiol induces cell death in human lung cancer cells and cancer stem cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9ce057d62cca42dcbd7f48daa0063d92
work_keys_str_mv	AT husseinhamad cannabidiolinducescelldeathinhumanlungcancercellsandcancerstemcells AT birgittebrinkmannolsen cannabidiolinducescelldeathinhumanlungcancercellsandcancerstemcells
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Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells

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