Reducing <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Virulence through Targeted Dysregulation of the Conidiation Pathway

Reducing <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Virulence through Targeted Dysregulation of the Conidiation Pathway

ABSTRACT Inhalation of conidia of the opportunistic mold Aspergillus fumigatus by immunocompromised hosts can lead to invasive pulmonary disease. Inhaled conidia that escape immune defenses germinate to form filamentous hyphae that invade lung tissues. Conidiation rarely occurs during invasive infec...

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Autores principales: James I. P. Stewart, Vinicius M. Fava, Joshua D. Kerkaert, Adithya S. Subramanian, Fabrice N. Gravelat, Melanie Lehoux, P. Lynne Howell, Robert A. Cramer, Donald C. Sheppard
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Aspergillus fumigatus
RNA sequencing
conidiation
drug targets
inducible gene expression
opportunistic pathogen
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/9ce0b03a0eff449bb4e6cf7bbbc2a825
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