Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease

Abstract An influenza vaccination might reduce the risk of incident peripheral arterial occlusive disease (PAOD) in patients with chronic kidney disease (CKD), but supporting evidence is limited. This case-crossover study analyzed data from Taiwan’s real-world National Health Insurance Research Data...

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Autores principales:	Ping-Jen Hu, Chia-Hsien Chen, Chung-Shun Wong, Tzu-Ting Chen, Mei-Yi Wu, Li-Chin Sung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ce13e9cae8544bf80b2fa938f7bf3f8
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spelling	oai:doaj.org-article:9ce13e9cae8544bf80b2fa938f7bf3f82021-12-02T11:35:40ZInfluenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease10.1038/s41598-021-84285-82045-2322https://doaj.org/article/9ce13e9cae8544bf80b2fa938f7bf3f82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84285-8https://doaj.org/toc/2045-2322Abstract An influenza vaccination might reduce the risk of incident peripheral arterial occlusive disease (PAOD) in patients with chronic kidney disease (CKD), but supporting evidence is limited. This case-crossover study analyzed data from Taiwan’s real-world National Health Insurance Research Database. This study included elderly (≥ 67 years old) patients with CKD having incident PAOD from January 1, 2006, to June 30, 2015. We defined 1 year before PAOD onset as the index date for the self-control group. A conditional logistic regression model was used to investigate exposure to an influenza vaccination for estimating the risk for incident PAOD following vaccination. In total, this study included 46,782 elderly patients with CKD having incident PAOD. The odds ratios for incident PAOD were 0.85 (95% confidence interval 0.77–0.94), 0.85 (0.79–0.92), 0.84 (0.79–0.90), and 0.85 (0.81–0.90) at 1, 2, 3, and 4 months after an influenza vaccination, respectively. We observed consistent results for the subgroups of patients with CKD and concomitant diabetes. However, we did not observe any beneficial effects of influenza vaccination in patients with advanced CKD or end-stage renal disease. This study demonstrated that influenza vaccination may be associated with a reduced risk of incident PAOD among patients with early-stage CKD.Ping-Jen HuChia-Hsien ChenChung-Shun WongTzu-Ting ChenMei-Yi WuLi-Chin SungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ping-Jen Hu Chia-Hsien Chen Chung-Shun Wong Tzu-Ting Chen Mei-Yi Wu Li-Chin Sung Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
description	Abstract An influenza vaccination might reduce the risk of incident peripheral arterial occlusive disease (PAOD) in patients with chronic kidney disease (CKD), but supporting evidence is limited. This case-crossover study analyzed data from Taiwan’s real-world National Health Insurance Research Database. This study included elderly (≥ 67 years old) patients with CKD having incident PAOD from January 1, 2006, to June 30, 2015. We defined 1 year before PAOD onset as the index date for the self-control group. A conditional logistic regression model was used to investigate exposure to an influenza vaccination for estimating the risk for incident PAOD following vaccination. In total, this study included 46,782 elderly patients with CKD having incident PAOD. The odds ratios for incident PAOD were 0.85 (95% confidence interval 0.77–0.94), 0.85 (0.79–0.92), 0.84 (0.79–0.90), and 0.85 (0.81–0.90) at 1, 2, 3, and 4 months after an influenza vaccination, respectively. We observed consistent results for the subgroups of patients with CKD and concomitant diabetes. However, we did not observe any beneficial effects of influenza vaccination in patients with advanced CKD or end-stage renal disease. This study demonstrated that influenza vaccination may be associated with a reduced risk of incident PAOD among patients with early-stage CKD.
format	article
author	Ping-Jen Hu Chia-Hsien Chen Chung-Shun Wong Tzu-Ting Chen Mei-Yi Wu Li-Chin Sung
author_facet	Ping-Jen Hu Chia-Hsien Chen Chung-Shun Wong Tzu-Ting Chen Mei-Yi Wu Li-Chin Sung
author_sort	Ping-Jen Hu
title	Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
title_short	Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
title_full	Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
title_fullStr	Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
title_full_unstemmed	Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
title_sort	influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ce13e9cae8544bf80b2fa938f7bf3f8
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Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease

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