Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and ext...

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Main Authors:	Mubeen M. Mosaheb, Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, Matthias Gromeier
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/9ce93ce8bbd34e53a699a9500f6bbbbf
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spelling	oai:doaj.org-article:9ce93ce8bbd34e53a699a9500f6bbbbf2021-12-02T16:49:16ZGenetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity10.1038/s41467-019-13939-z2041-1723https://doaj.org/article/9ce93ce8bbd34e53a699a9500f6bbbbf2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13939-zhttps://doaj.org/toc/2041-1723Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.Mubeen M. MosahebElena Y. DobrikovaMichael C. BrownYuanfan YangJana CableHideho OkadaSmita K. NairDarell D. BignerDavid M. AshleyMatthias GromeierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mubeen M. Mosaheb Elena Y. Dobrikova Michael C. Brown Yuanfan Yang Jana Cable Hideho Okada Smita K. Nair Darell D. Bigner David M. Ashley Matthias Gromeier Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
description	Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.
format	article
author	Mubeen M. Mosaheb Elena Y. Dobrikova Michael C. Brown Yuanfan Yang Jana Cable Hideho Okada Smita K. Nair Darell D. Bigner David M. Ashley Matthias Gromeier
author_facet	Mubeen M. Mosaheb Elena Y. Dobrikova Michael C. Brown Yuanfan Yang Jana Cable Hideho Okada Smita K. Nair Darell D. Bigner David M. Ashley Matthias Gromeier
author_sort	Mubeen M. Mosaheb
title	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_short	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_full	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_fullStr	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_full_unstemmed	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_sort	genetically stable poliovirus vectors activate dendritic cells and prime antitumor cd8 t cell immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9ce93ce8bbd34e53a699a9500f6bbbbf
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Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

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