Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia

Background: Measuring dengue virus transmission in endemic areas is a difficult task as many variables drive transmission, and often are not independent of one another. Objectives: We aimed to determine the utility of vectorial capacity to explain the observed dengue infection rates in three hyperen...

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Autores principales:	Victor Hugo Peña-García, Irma Sánchez-Vargas, Rebecca Christofferson, William C. Black IV, Sair Arboleda, Omar Triana-Chavez
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2019
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/9cecceaf3907458b9326226edac872ab
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spelling	oai:doaj.org-article:9cecceaf3907458b9326226edac872ab2021-12-02T03:22:32ZEstimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia2214-999610.5334/aogh.2339https://doaj.org/article/9cecceaf3907458b9326226edac872ab2019-03-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2339https://doaj.org/toc/2214-9996Background: Measuring dengue virus transmission in endemic areas is a difficult task as many variables drive transmission, and often are not independent of one another. Objectives: We aimed to determine the utility of vectorial capacity to explain the observed dengue infection rates in three hyperendemic cities in Colombia, and tested hypotheses related to three variables: mosquito density, effective vector competence, and biting rate. Methods: We estimated two of the most influential entomological variables related to cumulative vectorial capacity, which is a modification of the traditional vectorial capacity equation, of three Colombian mosquito populations. Laboratory studies were undertaken to measure vector competence and man biting rate of local mosquito populations. In addition, the assessment of cumulative vectorial capacity also incorporated site-specific estimations of mosquito density and the probability of daily survival from previous studies conducted in those cities. Findings: We found that the biting rates and mosquito infection rates differed among populations of mosquitoes from these three cities, resulting in differences in the site-specific measures of transmission potential. Specifically, we found that using site-specific entomological measures to populate the cumulative vectorial capacity equation was best at recapitulating observed mosquito infection rates when mosquito density was discounted compared to when we incorporated site-specific density measures. Conclusions: Specific mosquito-biting rate is likely sufficient to explain transmission differences in these three cities, confirming that this parameter is a critical parameter when predicting and assessing dengue transmission in three Colombian cities with different field observed transmission patterns.Victor Hugo Peña-GarcíaIrma Sánchez-VargasRebecca ChristoffersonWilliam C. Black IVSair ArboledaOmar Triana-ChavezUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 85, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Victor Hugo Peña-García Irma Sánchez-Vargas Rebecca Christofferson William C. Black IV Sair Arboleda Omar Triana-Chavez Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia
description	Background: Measuring dengue virus transmission in endemic areas is a difficult task as many variables drive transmission, and often are not independent of one another. Objectives: We aimed to determine the utility of vectorial capacity to explain the observed dengue infection rates in three hyperendemic cities in Colombia, and tested hypotheses related to three variables: mosquito density, effective vector competence, and biting rate. Methods: We estimated two of the most influential entomological variables related to cumulative vectorial capacity, which is a modification of the traditional vectorial capacity equation, of three Colombian mosquito populations. Laboratory studies were undertaken to measure vector competence and man biting rate of local mosquito populations. In addition, the assessment of cumulative vectorial capacity also incorporated site-specific estimations of mosquito density and the probability of daily survival from previous studies conducted in those cities. Findings: We found that the biting rates and mosquito infection rates differed among populations of mosquitoes from these three cities, resulting in differences in the site-specific measures of transmission potential. Specifically, we found that using site-specific entomological measures to populate the cumulative vectorial capacity equation was best at recapitulating observed mosquito infection rates when mosquito density was discounted compared to when we incorporated site-specific density measures. Conclusions: Specific mosquito-biting rate is likely sufficient to explain transmission differences in these three cities, confirming that this parameter is a critical parameter when predicting and assessing dengue transmission in three Colombian cities with different field observed transmission patterns.
format	article
author	Victor Hugo Peña-García Irma Sánchez-Vargas Rebecca Christofferson William C. Black IV Sair Arboleda Omar Triana-Chavez
author_facet	Victor Hugo Peña-García Irma Sánchez-Vargas Rebecca Christofferson William C. Black IV Sair Arboleda Omar Triana-Chavez
author_sort	Victor Hugo Peña-García
title	Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia
title_short	Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia
title_full	Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia
title_fullStr	Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia
title_full_unstemmed	Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia
title_sort	estimation of denv-2 transmission as a function of site-specific entomological parameters from three cities in colombia
publisher	Ubiquity Press
publishDate	2019
url	https://doaj.org/article/9cecceaf3907458b9326226edac872ab
work_keys_str_mv	AT victorhugopenagarcia estimationofdenv2transmissionasafunctionofsitespecificentomologicalparametersfromthreecitiesincolombia AT irmasanchezvargas estimationofdenv2transmissionasafunctionofsitespecificentomologicalparametersfromthreecitiesincolombia AT rebeccachristofferson estimationofdenv2transmissionasafunctionofsitespecificentomologicalparametersfromthreecitiesincolombia AT williamcblackiv estimationofdenv2transmissionasafunctionofsitespecificentomologicalparametersfromthreecitiesincolombia AT sairarboleda estimationofdenv2transmissionasafunctionofsitespecificentomologicalparametersfromthreecitiesincolombia AT omartrianachavez estimationofdenv2transmissionasafunctionofsitespecificentomologicalparametersfromthreecitiesincolombia
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Estimation of DENV-2 Transmission as a Function of Site-Specific Entomological Parameters from Three Cities in Colombia

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