IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

ER stress and UPR are implicated in various cancers. Here, the authors show that one of the canonical UPR pathways, IRE1α-XBP1 regulates c-MYC signaling to promote prostate tumorigenesis, and pharmacological inhibition of IRE1α with MKC8866 inhibits prostate cancer growth and synergizes with clinica...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xia Sheng, Hatice Zeynep Nenseth, Su Qu, Omer F. Kuzu, Turid Frahnow, Lukas Simon, Stephanie Greene, Qingping Zeng, Ladan Fazli, Paul S. Rennie, Ian G. Mills, Håvard Danielsen, Fabian Theis, John B. Patterson, Yang Jin, Fahri Saatcioglu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ced43e64be24399a78c2bfb98856c69
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ced43e64be24399a78c2bfb98856c69
record_format	dspace
spelling	oai:doaj.org-article:9ced43e64be24399a78c2bfb98856c692021-12-02T15:35:12ZIRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling10.1038/s41467-018-08152-32041-1723https://doaj.org/article/9ced43e64be24399a78c2bfb98856c692019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08152-3https://doaj.org/toc/2041-1723ER stress and UPR are implicated in various cancers. Here, the authors show that one of the canonical UPR pathways, IRE1α-XBP1 regulates c-MYC signaling to promote prostate tumorigenesis, and pharmacological inhibition of IRE1α with MKC8866 inhibits prostate cancer growth and synergizes with clinically used prostate cancer drugs.Xia ShengHatice Zeynep NensethSu QuOmer F. KuzuTurid FrahnowLukas SimonStephanie GreeneQingping ZengLadan FazliPaul S. RennieIan G. MillsHåvard DanielsenFabian TheisJohn B. PattersonYang JinFahri SaatciogluNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xia Sheng Hatice Zeynep Nenseth Su Qu Omer F. Kuzu Turid Frahnow Lukas Simon Stephanie Greene Qingping Zeng Ladan Fazli Paul S. Rennie Ian G. Mills Håvard Danielsen Fabian Theis John B. Patterson Yang Jin Fahri Saatcioglu IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
description	ER stress and UPR are implicated in various cancers. Here, the authors show that one of the canonical UPR pathways, IRE1α-XBP1 regulates c-MYC signaling to promote prostate tumorigenesis, and pharmacological inhibition of IRE1α with MKC8866 inhibits prostate cancer growth and synergizes with clinically used prostate cancer drugs.
format	article
author	Xia Sheng Hatice Zeynep Nenseth Su Qu Omer F. Kuzu Turid Frahnow Lukas Simon Stephanie Greene Qingping Zeng Ladan Fazli Paul S. Rennie Ian G. Mills Håvard Danielsen Fabian Theis John B. Patterson Yang Jin Fahri Saatcioglu
author_facet	Xia Sheng Hatice Zeynep Nenseth Su Qu Omer F. Kuzu Turid Frahnow Lukas Simon Stephanie Greene Qingping Zeng Ladan Fazli Paul S. Rennie Ian G. Mills Håvard Danielsen Fabian Theis John B. Patterson Yang Jin Fahri Saatcioglu
author_sort	Xia Sheng
title	IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
title_short	IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
title_full	IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
title_fullStr	IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
title_full_unstemmed	IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
title_sort	ire1α-xbp1s pathway promotes prostate cancer by activating c-myc signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9ced43e64be24399a78c2bfb98856c69
work_keys_str_mv	AT xiasheng ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT haticezeynepnenseth ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT suqu ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT omerfkuzu ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT turidfrahnow ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT lukassimon ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT stephaniegreene ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT qingpingzeng ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT ladanfazli ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT paulsrennie ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT iangmills ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT havarddanielsen ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT fabiantheis ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT johnbpatterson ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT yangjin ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling AT fahrisaatcioglu ire1axbp1spathwaypromotesprostatecancerbyactivatingcmycsignaling
_version_	1718386614589194240

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Ejemplares similares