Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens

Quorum sensing (QS) plays an essential role in virulence factor production, biofilm formation, and antimicrobial resistance. As a potent QS inhibitor, hordenine can inhibit both QS and biofilm formation in Pseudomonas aeruginosa and Serratia marcescens. In this work, we tested the QS inhibitory pote...

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Autores principales:	Yue Liu, Jun-Jian Li, Hong-Yuan Li, Shi-Ming Deng, Ai-Qun Jia
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Hordenine analogs Pseudomonas aeruginosa Serratia marcescens Quorum sensing inhibition QSAR Biofilm Biotechnology TP248.13-248.65 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9cee47318d7641dfa1c169303874c4f0
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spelling	oai:doaj.org-article:9cee47318d7641dfa1c169303874c4f02021-11-04T04:33:34ZQuorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens2405-805X10.1016/j.synbio.2021.09.010https://doaj.org/article/9cee47318d7641dfa1c169303874c4f02021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405805X21000624https://doaj.org/toc/2405-805XQuorum sensing (QS) plays an essential role in virulence factor production, biofilm formation, and antimicrobial resistance. As a potent QS inhibitor, hordenine can inhibit both QS and biofilm formation in Pseudomonas aeruginosa and Serratia marcescens. In this work, we tested the QS inhibitory potential of 27 hordenine analogs against QS and biofilm formation in P. aeruginosa and S. marcescens. Among the tested analogs, seven (12, 28, 27, 26, 2, 23, and 7) exhibited strong QS inhibitory activity against P. aeruginosa, five of which (12, 28, 27, 26, and 2) showed better inhibitory activity than hordenine. In addition, seven analogs (28, 12, 23, 7, 26, 2, and 27) exhibited better biofilm inhibition against P. aeruginosa than hordenine. Four analogs (7, 28, 2, and 12) showed QS inhibitory activity against S. marcescens, two of which (7 and 28) demonstrated better inhibitory activity than hordenine. Furthermore, analog 7 showed similar biofilm inhibition against S. marcescens as hordenine. Structure-activity relationship (SAR) analysis indicated that the inhibitory activities of the analogs were related to four factors, i.e., carbon chain length, presence or absence of an α,β-CC bond, amino group with/without lipophilic group, such as methyl group, and hydroxyl group in benzene ring.Yue LiuJun-Jian LiHong-Yuan LiShi-Ming DengAi-Qun JiaKeAi Communications Co., Ltd.articleHordenine analogsPseudomonas aeruginosaSerratia marcescensQuorum sensing inhibitionQSARBiofilmBiotechnologyTP248.13-248.65Biology (General)QH301-705.5ENSynthetic and Systems Biotechnology, Vol 6, Iss 4, Pp 360-368 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hordenine analogs Pseudomonas aeruginosa Serratia marcescens Quorum sensing inhibition QSAR Biofilm Biotechnology TP248.13-248.65 Biology (General) QH301-705.5
spellingShingle	Hordenine analogs Pseudomonas aeruginosa Serratia marcescens Quorum sensing inhibition QSAR Biofilm Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Yue Liu Jun-Jian Li Hong-Yuan Li Shi-Ming Deng Ai-Qun Jia Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens
description	Quorum sensing (QS) plays an essential role in virulence factor production, biofilm formation, and antimicrobial resistance. As a potent QS inhibitor, hordenine can inhibit both QS and biofilm formation in Pseudomonas aeruginosa and Serratia marcescens. In this work, we tested the QS inhibitory potential of 27 hordenine analogs against QS and biofilm formation in P. aeruginosa and S. marcescens. Among the tested analogs, seven (12, 28, 27, 26, 2, 23, and 7) exhibited strong QS inhibitory activity against P. aeruginosa, five of which (12, 28, 27, 26, and 2) showed better inhibitory activity than hordenine. In addition, seven analogs (28, 12, 23, 7, 26, 2, and 27) exhibited better biofilm inhibition against P. aeruginosa than hordenine. Four analogs (7, 28, 2, and 12) showed QS inhibitory activity against S. marcescens, two of which (7 and 28) demonstrated better inhibitory activity than hordenine. Furthermore, analog 7 showed similar biofilm inhibition against S. marcescens as hordenine. Structure-activity relationship (SAR) analysis indicated that the inhibitory activities of the analogs were related to four factors, i.e., carbon chain length, presence or absence of an α,β-CC bond, amino group with/without lipophilic group, such as methyl group, and hydroxyl group in benzene ring.
format	article
author	Yue Liu Jun-Jian Li Hong-Yuan Li Shi-Ming Deng Ai-Qun Jia
author_facet	Yue Liu Jun-Jian Li Hong-Yuan Li Shi-Ming Deng Ai-Qun Jia
author_sort	Yue Liu
title	Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens
title_short	Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens
title_full	Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens
title_fullStr	Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens
title_full_unstemmed	Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens
title_sort	quorum sensing inhibition of hordenine analogs on pseudomonas aeruginosa and serratia marcescens
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/9cee47318d7641dfa1c169303874c4f0
work_keys_str_mv	AT yueliu quorumsensinginhibitionofhordenineanalogsonpseudomonasaeruginosaandserratiamarcescens AT junjianli quorumsensinginhibitionofhordenineanalogsonpseudomonasaeruginosaandserratiamarcescens AT hongyuanli quorumsensinginhibitionofhordenineanalogsonpseudomonasaeruginosaandserratiamarcescens AT shimingdeng quorumsensinginhibitionofhordenineanalogsonpseudomonasaeruginosaandserratiamarcescens AT aiqunjia quorumsensinginhibitionofhordenineanalogsonpseudomonasaeruginosaandserratiamarcescens
_version_	1718445289248915456

Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens

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