Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.

Parkinson's disease (PD) is caused by the selective loss of dopaminergic neurons in the substantia nigra (SN) and the depletion of striatal dopamine (DA). Acupuncture, as an alternative therapy for PD, has beneficial effects in both PD patients and PD animal models, although the underlying mech...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Seung-Nam Kim, Ah-Reum Doo, Ji-Yeun Park, Hyungjin Bae, Younbyoung Chae, Insop Shim, Hyangsook Lee, Woongjoon Moon, Hyejung Lee, Hi-Joon Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ceed0d1ae8741f2a170cb090bec83e6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ceed0d1ae8741f2a170cb090bec83e6
record_format	dspace
spelling	oai:doaj.org-article:9ceed0d1ae8741f2a170cb090bec83e62021-11-18T07:33:45ZAcupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.1932-620310.1371/journal.pone.0027566https://doaj.org/article/9ceed0d1ae8741f2a170cb090bec83e62011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22132113/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Parkinson's disease (PD) is caused by the selective loss of dopaminergic neurons in the substantia nigra (SN) and the depletion of striatal dopamine (DA). Acupuncture, as an alternative therapy for PD, has beneficial effects in both PD patients and PD animal models, although the underlying mechanisms therein remain uncertain. The present study investigated whether acupuncture treatment affected dopamine neurotransmission in a PD mouse model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We found that acupuncture treatment at acupoint GB34 improved motor function with accompanying dopaminergic neuron protection against MPTP but did not restore striatal dopamine depletion. Instead, acupuncture treatment increased dopamine release that in turn, may lead to the enhancement of dopamine availability in the synaptic cleft. Moreover, acupuncture treatment mitigated MPTP-induced abnormal postsynaptic changes, suggesting that acupuncture treatment may increase postsynaptic dopamine neurotransmission and facilitate the normalization of basal ganglia activity. These results suggest that the acupuncture-induced enhancement of synaptic dopamine availability may play a critical role in motor function improvement against MPTP.Seung-Nam KimAh-Reum DooJi-Yeun ParkHyungjin BaeYounbyoung ChaeInsop ShimHyangsook LeeWoongjoon MoonHyejung LeeHi-Joon ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27566 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seung-Nam Kim Ah-Reum Doo Ji-Yeun Park Hyungjin Bae Younbyoung Chae Insop Shim Hyangsook Lee Woongjoon Moon Hyejung Lee Hi-Joon Park Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.
description	Parkinson's disease (PD) is caused by the selective loss of dopaminergic neurons in the substantia nigra (SN) and the depletion of striatal dopamine (DA). Acupuncture, as an alternative therapy for PD, has beneficial effects in both PD patients and PD animal models, although the underlying mechanisms therein remain uncertain. The present study investigated whether acupuncture treatment affected dopamine neurotransmission in a PD mouse model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We found that acupuncture treatment at acupoint GB34 improved motor function with accompanying dopaminergic neuron protection against MPTP but did not restore striatal dopamine depletion. Instead, acupuncture treatment increased dopamine release that in turn, may lead to the enhancement of dopamine availability in the synaptic cleft. Moreover, acupuncture treatment mitigated MPTP-induced abnormal postsynaptic changes, suggesting that acupuncture treatment may increase postsynaptic dopamine neurotransmission and facilitate the normalization of basal ganglia activity. These results suggest that the acupuncture-induced enhancement of synaptic dopamine availability may play a critical role in motor function improvement against MPTP.
format	article
author	Seung-Nam Kim Ah-Reum Doo Ji-Yeun Park Hyungjin Bae Younbyoung Chae Insop Shim Hyangsook Lee Woongjoon Moon Hyejung Lee Hi-Joon Park
author_facet	Seung-Nam Kim Ah-Reum Doo Ji-Yeun Park Hyungjin Bae Younbyoung Chae Insop Shim Hyangsook Lee Woongjoon Moon Hyejung Lee Hi-Joon Park
author_sort	Seung-Nam Kim
title	Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.
title_short	Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.
title_full	Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.
title_fullStr	Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.
title_full_unstemmed	Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.
title_sort	acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/9ceed0d1ae8741f2a170cb090bec83e6
work_keys_str_mv	AT seungnamkim acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT ahreumdoo acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT jiyeunpark acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT hyungjinbae acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT younbyoungchae acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT insopshim acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT hyangsooklee acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT woongjoonmoon acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT hyejunglee acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease AT hijoonpark acupunctureenhancesthesynapticdopamineavailabilitytoimprovemotorfunctioninamousemodelofparkinsonsdisease
_version_	1718423303006191616

Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease.

Ejemplares similares