Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy

Introduction Despite the fact that cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) is a proven method for detecting myocardial fibrosis, there is a need for new and reliable serological biomarkers. Circulating miRNAs could be a practical and attractive alternative. The...

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Autores principales:	Zofia M. Szemraj-Rogucka, Janusz Szemraj, Konrad Masiarek, Agata Majos
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	mirna cardiac magnetic resonance left ventricular non-compaction late gadolinium enhancement Medicine R
Acceso en línea:	https://doaj.org/article/9cf27682f3ac4f0bb516ff0b52f4d880
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spelling	oai:doaj.org-article:9cf27682f3ac4f0bb516ff0b52f4d8802021-12-02T16:59:26ZCirculating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy1734-19221896-915110.5114/aoms.2019.82919https://doaj.org/article/9cf27682f3ac4f0bb516ff0b52f4d8802019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Circulating-microRNAs-as-biomarkers-for-myocardial-fibrosis-in-patients-with-left,69682,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Despite the fact that cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) is a proven method for detecting myocardial fibrosis, there is a need for new and reliable serological biomarkers. Circulating miRNAs could be a practical and attractive alternative. The purpose of the study was to assess the miRNAs well established in myocardial fibrosis – miR-21, miR-29a, miR-30d and miR-133a – in the plasma of patients with left ventricular non-compaction (LVNC) that have areas of LGE assessed by CMR. Material and methods We prospectively enrolled 13 adult patients (9 males and 4 females; mean age: 39 ±11.7 years) considered to meet standard CMR criteria for LVNC and 10 healthy age- and sex-matched subjects. All LVNC patients and control subjects underwent CMR examination and the measurement of peripheral plasma levels of 4 miRNAs: miR-21, miR-29a, miR-30d and miR-133a. Results The LGE was present in 9 of the 13 (69.2%) LVNC patients, and most often located in the ventricular septum. Compared with LGE-negative patients, LGE-positive patients had significantly lower LVEF (28.3 ±13.3% vs. 53.5 ±14.9%, p = 0.0113) and greater LV end-diastolic diameter (67.8 ±9.5 mm vs. 57 ±2.2 mm, p = 0.01). Significant up-regulation of all 4 miRNAs was observed among LGE-positive patients vs. LGE-negative patients: miR-21 (p = 0.007), miR-29a (p = 0.0001), miR-30d (p = 0.001) and miR-133a (p = 0.0003). Conclusions The up-regulation of miR-21, miR-29a, miR-30d and miR-133a indicates the presence of LGE in LVNC patients, and therefore they may serve as potential biomarkers for myocardial fibrosis.Zofia M. Szemraj-RoguckaJanusz SzemrajKonrad MasiarekAgata MajosTermedia Publishing Housearticlemirnacardiac magnetic resonanceleft ventricular non-compactionlate gadolinium enhancementleft ventricular non-compactionlate gadolinium enhancementMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 376-384 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	mirna cardiac magnetic resonance left ventricular non-compaction late gadolinium enhancement left ventricular non-compaction late gadolinium enhancement Medicine R
spellingShingle	mirna cardiac magnetic resonance left ventricular non-compaction late gadolinium enhancement left ventricular non-compaction late gadolinium enhancement Medicine R Zofia M. Szemraj-Rogucka Janusz Szemraj Konrad Masiarek Agata Majos Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy
description	Introduction Despite the fact that cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) is a proven method for detecting myocardial fibrosis, there is a need for new and reliable serological biomarkers. Circulating miRNAs could be a practical and attractive alternative. The purpose of the study was to assess the miRNAs well established in myocardial fibrosis – miR-21, miR-29a, miR-30d and miR-133a – in the plasma of patients with left ventricular non-compaction (LVNC) that have areas of LGE assessed by CMR. Material and methods We prospectively enrolled 13 adult patients (9 males and 4 females; mean age: 39 ±11.7 years) considered to meet standard CMR criteria for LVNC and 10 healthy age- and sex-matched subjects. All LVNC patients and control subjects underwent CMR examination and the measurement of peripheral plasma levels of 4 miRNAs: miR-21, miR-29a, miR-30d and miR-133a. Results The LGE was present in 9 of the 13 (69.2%) LVNC patients, and most often located in the ventricular septum. Compared with LGE-negative patients, LGE-positive patients had significantly lower LVEF (28.3 ±13.3% vs. 53.5 ±14.9%, p = 0.0113) and greater LV end-diastolic diameter (67.8 ±9.5 mm vs. 57 ±2.2 mm, p = 0.01). Significant up-regulation of all 4 miRNAs was observed among LGE-positive patients vs. LGE-negative patients: miR-21 (p = 0.007), miR-29a (p = 0.0001), miR-30d (p = 0.001) and miR-133a (p = 0.0003). Conclusions The up-regulation of miR-21, miR-29a, miR-30d and miR-133a indicates the presence of LGE in LVNC patients, and therefore they may serve as potential biomarkers for myocardial fibrosis.
format	article
author	Zofia M. Szemraj-Rogucka Janusz Szemraj Konrad Masiarek Agata Majos
author_facet	Zofia M. Szemraj-Rogucka Janusz Szemraj Konrad Masiarek Agata Majos
author_sort	Zofia M. Szemraj-Rogucka
title	Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy
title_short	Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy
title_full	Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy
title_fullStr	Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy
title_full_unstemmed	Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy
title_sort	circulating micrornas as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/9cf27682f3ac4f0bb516ff0b52f4d880
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Circulating microRNAs as biomarkers for myocardial fibrosis in patients with left ventricular non-compaction cardiomyopathy

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