A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

Progressive remodeling and calcification of the aortic valve leads to calcific aortic valve stenosis (CAVS) and, ultimately, heart failure. In a combined GWAS and TWAS approach, Thériault et al. identify PALMD as a candidate causal gene for CAVS, which is further supported by Mendelian randomization...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Sébastien Thériault, Nathalie Gaudreault, Maxime Lamontagne, Mickael Rosa, Marie-Chloé Boulanger, David Messika-Zeitoun, Marie-Annick Clavel, Romain Capoulade, François Dagenais, Philippe Pibarot, Patrick Mathieu, Yohan Bossé
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9cf3c3c3713643dabfb19515fe5fe760
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:9cf3c3c3713643dabfb19515fe5fe760
record_format	dspace
spelling	oai:doaj.org-article:9cf3c3c3713643dabfb19515fe5fe7602021-12-02T14:38:53ZA transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis10.1038/s41467-018-03260-62041-1723https://doaj.org/article/9cf3c3c3713643dabfb19515fe5fe7602018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03260-6https://doaj.org/toc/2041-1723Progressive remodeling and calcification of the aortic valve leads to calcific aortic valve stenosis (CAVS) and, ultimately, heart failure. In a combined GWAS and TWAS approach, Thériault et al. identify PALMD as a candidate causal gene for CAVS, which is further supported by Mendelian randomization.Sébastien ThériaultNathalie GaudreaultMaxime LamontagneMickael RosaMarie-Chloé BoulangerDavid Messika-ZeitounMarie-Annick ClavelRomain CapouladeFrançois DagenaisPhilippe PibarotPatrick MathieuYohan BosséNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sébastien Thériault Nathalie Gaudreault Maxime Lamontagne Mickael Rosa Marie-Chloé Boulanger David Messika-Zeitoun Marie-Annick Clavel Romain Capoulade François Dagenais Philippe Pibarot Patrick Mathieu Yohan Bossé A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis
description	Progressive remodeling and calcification of the aortic valve leads to calcific aortic valve stenosis (CAVS) and, ultimately, heart failure. In a combined GWAS and TWAS approach, Thériault et al. identify PALMD as a candidate causal gene for CAVS, which is further supported by Mendelian randomization.
format	article
author	Sébastien Thériault Nathalie Gaudreault Maxime Lamontagne Mickael Rosa Marie-Chloé Boulanger David Messika-Zeitoun Marie-Annick Clavel Romain Capoulade François Dagenais Philippe Pibarot Patrick Mathieu Yohan Bossé
author_facet	Sébastien Thériault Nathalie Gaudreault Maxime Lamontagne Mickael Rosa Marie-Chloé Boulanger David Messika-Zeitoun Marie-Annick Clavel Romain Capoulade François Dagenais Philippe Pibarot Patrick Mathieu Yohan Bossé
author_sort	Sébastien Thériault
title	A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis
title_short	A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis
title_full	A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis
title_fullStr	A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis
title_full_unstemmed	A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis
title_sort	transcriptome-wide association study identifies palmd as a susceptibility gene for calcific aortic valve stenosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9cf3c3c3713643dabfb19515fe5fe760
work_keys_str_mv	AT sebastientheriault atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT nathaliegaudreault atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT maximelamontagne atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT mickaelrosa atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT mariechloeboulanger atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT davidmessikazeitoun atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT marieannickclavel atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT romaincapoulade atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT francoisdagenais atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT philippepibarot atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT patrickmathieu atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT yohanbosse atranscriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT sebastientheriault transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT nathaliegaudreault transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT maximelamontagne transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT mickaelrosa transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT mariechloeboulanger transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT davidmessikazeitoun transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT marieannickclavel transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT romaincapoulade transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT francoisdagenais transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT philippepibarot transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT patrickmathieu transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis AT yohanbosse transcriptomewideassociationstudyidentifiespalmdasasusceptibilitygeneforcalcificaorticvalvestenosis
_version_	1718390852069359616

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

Documents similaires