A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

Progressive remodeling and calcification of the aortic valve leads to calcific aortic valve stenosis (CAVS) and, ultimately, heart failure. In a combined GWAS and TWAS approach, Thériault et al. identify PALMD as a candidate causal gene for CAVS, which is further supported by Mendelian randomization...

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Auteurs principaux: Sébastien Thériault, Nathalie Gaudreault, Maxime Lamontagne, Mickael Rosa, Marie-Chloé Boulanger, David Messika-Zeitoun, Marie-Annick Clavel, Romain Capoulade, François Dagenais, Philippe Pibarot, Patrick Mathieu, Yohan Bossé
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
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Accès en ligne:https://doaj.org/article/9cf3c3c3713643dabfb19515fe5fe760
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https://doaj.org/article/9cf3c3c3713643dabfb19515fe5fe760

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