Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures

ASH1L haploinsufficiency is strongly linked to autism, despite the unknown mechanism. Here, the authors show that ASH1L deficiency in prefrontal cortex causes the downregulation of synaptic genes, leading to seizures, which is rescued by chemogenetic and pharmacological restoration of excitation/inh...

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Autores principales:	Luye Qin, Jamal B. Williams, Tao Tan, Tiaotiao Liu, Qing Cao, Kaijie Ma, Zhen Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9cf490f4547141f4a572a7d190a6884a
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spelling	oai:doaj.org-article:9cf490f4547141f4a572a7d190a6884a2021-11-21T12:38:56ZDeficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures10.1038/s41467-021-26972-82041-1723https://doaj.org/article/9cf490f4547141f4a572a7d190a6884a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26972-8https://doaj.org/toc/2041-1723ASH1L haploinsufficiency is strongly linked to autism, despite the unknown mechanism. Here, the authors show that ASH1L deficiency in prefrontal cortex causes the downregulation of synaptic genes, leading to seizures, which is rescued by chemogenetic and pharmacological restoration of excitation/inhibition balance.Luye QinJamal B. WilliamsTao TanTiaotiao LiuQing CaoKaijie MaZhen YanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luye Qin Jamal B. Williams Tao Tan Tiaotiao Liu Qing Cao Kaijie Ma Zhen Yan Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
description	ASH1L haploinsufficiency is strongly linked to autism, despite the unknown mechanism. Here, the authors show that ASH1L deficiency in prefrontal cortex causes the downregulation of synaptic genes, leading to seizures, which is rescued by chemogenetic and pharmacological restoration of excitation/inhibition balance.
format	article
author	Luye Qin Jamal B. Williams Tao Tan Tiaotiao Liu Qing Cao Kaijie Ma Zhen Yan
author_facet	Luye Qin Jamal B. Williams Tao Tan Tiaotiao Liu Qing Cao Kaijie Ma Zhen Yan
author_sort	Luye Qin
title	Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
title_short	Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
title_full	Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
title_fullStr	Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
title_full_unstemmed	Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
title_sort	deficiency of autism risk factor ash1l in prefrontal cortex induces epigenetic aberrations and seizures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9cf490f4547141f4a572a7d190a6884a
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Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures

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