Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells

Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells

Neha N Parayath,1 Hayley Nehoff,1 Philipp Müller,1 Sebastien Taurin,1 Khaled Greish1,21Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Oncology, Faculty of Medicine, Suez Canal University, Ismaileya, EgyptAbstract: Drug delivery...

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Autores principales: Parayath NN, Nehoff H, Müller P, Taurin S, Greish K
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/9cf50af4d186441286ad76e0900a01a6
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spelling oai:doaj.org-article:9cf50af4d186441286ad76e0900a01a62021-12-02T05:02:16ZStyrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells1178-2013https://doaj.org/article/9cf50af4d186441286ad76e0900a01a62015-07-01T00:00:00Zhttp://www.dovepress.com/styrene-maleic-acid-micelles-as-a-nanocarrier-system-for-oral-anticanc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Neha N Parayath,1 Hayley Nehoff,1 Philipp Müller,1 Sebastien Taurin,1 Khaled Greish1,21Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Oncology, Faculty of Medicine, Suez Canal University, Ismaileya, EgyptAbstract: Drug delivery systems could potentially overcome low bioavailability and gastrointestinal toxicity, which are the major challenges for the development of oral anticancer drugs. Herein, we demonstrate the ability of styrene maleic acid (SMA) nanomicelles encapsulating epirubicin to traverse in vitro and ex vivo models of the intestinal epithelium without affecting the tissue integrity. Further, SMA micelles encapsulating a fluorescent dye dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) showed twofold higher accumulation in the liver and spleen, 15-fold higher accumulation in the tumor, and sixfold higher accumulation in the lung as compared with the free DiI, following oral administration in a mice xenograft breast cancer model. Additionally, SMA micelles showed colocalization with microfold (M)-cells and accumulation in Peyer’s patches, which together confirms the M-cell mediated uptake and transport of SMA micelles. Our results indicate that SMA micelles, showing dual uptake by enterocytes and M-cells, are a potential tool for safe oral anticancer drug delivery.Keywords: oral delivery, anticancer nanomedicine, enhanced permeability and retention effect, EPRParayath NNNehoff HMüller PTaurin SGreish KDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4653-4667 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Parayath NN
Nehoff H
Müller P
Taurin S
Greish K
Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells
description Neha N Parayath,1 Hayley Nehoff,1 Philipp Müller,1 Sebastien Taurin,1 Khaled Greish1,21Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; 2Department of Oncology, Faculty of Medicine, Suez Canal University, Ismaileya, EgyptAbstract: Drug delivery systems could potentially overcome low bioavailability and gastrointestinal toxicity, which are the major challenges for the development of oral anticancer drugs. Herein, we demonstrate the ability of styrene maleic acid (SMA) nanomicelles encapsulating epirubicin to traverse in vitro and ex vivo models of the intestinal epithelium without affecting the tissue integrity. Further, SMA micelles encapsulating a fluorescent dye dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) showed twofold higher accumulation in the liver and spleen, 15-fold higher accumulation in the tumor, and sixfold higher accumulation in the lung as compared with the free DiI, following oral administration in a mice xenograft breast cancer model. Additionally, SMA micelles showed colocalization with microfold (M)-cells and accumulation in Peyer’s patches, which together confirms the M-cell mediated uptake and transport of SMA micelles. Our results indicate that SMA micelles, showing dual uptake by enterocytes and M-cells, are a potential tool for safe oral anticancer drug delivery.Keywords: oral delivery, anticancer nanomedicine, enhanced permeability and retention effect, EPR
format article
author Parayath NN
Nehoff H
Müller P
Taurin S
Greish K
author_facet Parayath NN
Nehoff H
Müller P
Taurin S
Greish K
author_sort Parayath NN
title Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells
title_short Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells
title_full Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells
title_fullStr Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells
title_full_unstemmed Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells
title_sort styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and m-cells
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/9cf50af4d186441286ad76e0900a01a6
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AT muumlllerp styrenemaleicacidmicellesasananocarriersystemfororalanticancerdrugdeliveryndashdualuptakethroughenterocytesandmcells
AT taurins styrenemaleicacidmicellesasananocarriersystemfororalanticancerdrugdeliveryndashdualuptakethroughenterocytesandmcells
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