Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults

A systematic examination of the effects of traditional herbal medicines including their mechanisms could allow for their effective use and provide opportunities to develop new medicines. Coix seed has been suggested to promote spontaneous regression of viral skin infection. Purified oil from coix se...

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Autores principales:	Minami Jinnouchi, Taisei Miyahara, Yoshio Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	adlay pearl barley gut microbiota immune system herbal medicine Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/9cf5b9ef85874bba948d54e91c82212a
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spelling	oai:doaj.org-article:9cf5b9ef85874bba948d54e91c82212a2021-11-25T18:36:37ZCoix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults10.3390/nu131140792072-6643https://doaj.org/article/9cf5b9ef85874bba948d54e91c82212a2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4079https://doaj.org/toc/2072-6643A systematic examination of the effects of traditional herbal medicines including their mechanisms could allow for their effective use and provide opportunities to develop new medicines. Coix seed has been suggested to promote spontaneous regression of viral skin infection. Purified oil from coix seed has also been suggested to increase the peripheral CD4<sup>+</sup> lymphocytes. We, herein, attempt to shed more light on the way through which coix seed affects the human systemic immune function by hypothesizing that a central role to these changes could be played through changes in the gut microbiota. To that end, healthy adult males (<i>n</i> = 19) were divided into two groups; 11 of them consumed cooked coix seed (160 g per day) for 7 days (intervention), while the other eight were given no intervention. One week of coix seed consumption lead to an increase of the intestinal <i>Faecalibacterium</i> abundance and of the abundance (as % presence of overall peripheral lymphocytes) of CD3<sup>+</sup>CD8<sup>+</sup> cells, CD4<sup>+</sup> cells, CD4<sup>+</sup>CD25<sup>+</sup> cells, and naïve/memory T cell ratio. As the relationship of microbiota and skin infection has not been clarified, our findings could provide a clue to a mechanism through which coix seed could promote the spontaneous regression of viral skin infections.Minami JinnouchiTaisei MiyaharaYoshio SuzukiMDPI AGarticleadlaypearl barleygut microbiotaimmune systemherbal medicineNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4079, p 4079 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adlay pearl barley gut microbiota immune system herbal medicine Nutrition. Foods and food supply TX341-641
spellingShingle	adlay pearl barley gut microbiota immune system herbal medicine Nutrition. Foods and food supply TX341-641 Minami Jinnouchi Taisei Miyahara Yoshio Suzuki Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults
description	A systematic examination of the effects of traditional herbal medicines including their mechanisms could allow for their effective use and provide opportunities to develop new medicines. Coix seed has been suggested to promote spontaneous regression of viral skin infection. Purified oil from coix seed has also been suggested to increase the peripheral CD4<sup>+</sup> lymphocytes. We, herein, attempt to shed more light on the way through which coix seed affects the human systemic immune function by hypothesizing that a central role to these changes could be played through changes in the gut microbiota. To that end, healthy adult males (<i>n</i> = 19) were divided into two groups; 11 of them consumed cooked coix seed (160 g per day) for 7 days (intervention), while the other eight were given no intervention. One week of coix seed consumption lead to an increase of the intestinal <i>Faecalibacterium</i> abundance and of the abundance (as % presence of overall peripheral lymphocytes) of CD3<sup>+</sup>CD8<sup>+</sup> cells, CD4<sup>+</sup> cells, CD4<sup>+</sup>CD25<sup>+</sup> cells, and naïve/memory T cell ratio. As the relationship of microbiota and skin infection has not been clarified, our findings could provide a clue to a mechanism through which coix seed could promote the spontaneous regression of viral skin infections.
format	article
author	Minami Jinnouchi Taisei Miyahara Yoshio Suzuki
author_facet	Minami Jinnouchi Taisei Miyahara Yoshio Suzuki
author_sort	Minami Jinnouchi
title	Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults
title_short	Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults
title_full	Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults
title_fullStr	Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults
title_full_unstemmed	Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults
title_sort	coix seed consumption affects the gut microbiota and the peripheral lymphocyte subset profiles of healthy male adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9cf5b9ef85874bba948d54e91c82212a
work_keys_str_mv	AT minamijinnouchi coixseedconsumptionaffectsthegutmicrobiotaandtheperipherallymphocytesubsetprofilesofhealthymaleadults AT taiseimiyahara coixseedconsumptionaffectsthegutmicrobiotaandtheperipherallymphocytesubsetprofilesofhealthymaleadults AT yoshiosuzuki coixseedconsumptionaffectsthegutmicrobiotaandtheperipherallymphocytesubsetprofilesofhealthymaleadults
_version_	1718410906559315968

Coix Seed Consumption Affects the Gut Microbiota and the Peripheral Lymphocyte Subset Profiles of Healthy Male Adults

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