A novel and simple formula to predict liver mass in porcine experimental models
Abstract A primary limitation in hepatic surgery is leaving a remnant liver of adequate size and function. Experimental models have been designed to study processes of liver injury and regeneration in this context, yet a formula to accurately calculate liver mass in an animal model is lacking. This...
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Nature Portfolio
2019
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oai:doaj.org-article:9cfa4f64a12640d6b37b2db46b4171a82021-12-02T15:07:53ZA novel and simple formula to predict liver mass in porcine experimental models10.1038/s41598-019-48781-22045-2322https://doaj.org/article/9cfa4f64a12640d6b37b2db46b4171a82019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48781-2https://doaj.org/toc/2045-2322Abstract A primary limitation in hepatic surgery is leaving a remnant liver of adequate size and function. Experimental models have been designed to study processes of liver injury and regeneration in this context, yet a formula to accurately calculate liver mass in an animal model is lacking. This study aims to create a novel and simple formula to estimate the mass of the native liver in a species of pigs commonly used in experimental liver surgery protocols. Using data from 200 male weanling Landrace-Large White hybrid pigs, multiple linear regression analysis is used to generate the formula. Clinical features used as variables for the predictive model are body mass and length. The final formula for pig liver mass is as follows: Liver mass (g) = 26.34232 * Body mass (kg) – 1.270629 * Length (cm) + 163.0076; R2 = 0.7307. This formula for porcine liver mass is simple to use and may be helpful in studies using animals of similar characteristics to evaluate restoration of liver mass following major hepatectomy.Lilia Martínez de la MazaVerónica PradoAmelia J. HessheimerJavier MuñozJuan Carlos García-ValdecasasConstantino FondevilaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-6 (2019) |
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Medicine R Science Q |
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Medicine R Science Q Lilia Martínez de la Maza Verónica Prado Amelia J. Hessheimer Javier Muñoz Juan Carlos García-Valdecasas Constantino Fondevila A novel and simple formula to predict liver mass in porcine experimental models |
| description |
Abstract A primary limitation in hepatic surgery is leaving a remnant liver of adequate size and function. Experimental models have been designed to study processes of liver injury and regeneration in this context, yet a formula to accurately calculate liver mass in an animal model is lacking. This study aims to create a novel and simple formula to estimate the mass of the native liver in a species of pigs commonly used in experimental liver surgery protocols. Using data from 200 male weanling Landrace-Large White hybrid pigs, multiple linear regression analysis is used to generate the formula. Clinical features used as variables for the predictive model are body mass and length. The final formula for pig liver mass is as follows: Liver mass (g) = 26.34232 * Body mass (kg) – 1.270629 * Length (cm) + 163.0076; R2 = 0.7307. This formula for porcine liver mass is simple to use and may be helpful in studies using animals of similar characteristics to evaluate restoration of liver mass following major hepatectomy. |
| format |
article |
| author |
Lilia Martínez de la Maza Verónica Prado Amelia J. Hessheimer Javier Muñoz Juan Carlos García-Valdecasas Constantino Fondevila |
| author_facet |
Lilia Martínez de la Maza Verónica Prado Amelia J. Hessheimer Javier Muñoz Juan Carlos García-Valdecasas Constantino Fondevila |
| author_sort |
Lilia Martínez de la Maza |
| title |
A novel and simple formula to predict liver mass in porcine experimental models |
| title_short |
A novel and simple formula to predict liver mass in porcine experimental models |
| title_full |
A novel and simple formula to predict liver mass in porcine experimental models |
| title_fullStr |
A novel and simple formula to predict liver mass in porcine experimental models |
| title_full_unstemmed |
A novel and simple formula to predict liver mass in porcine experimental models |
| title_sort |
novel and simple formula to predict liver mass in porcine experimental models |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/9cfa4f64a12640d6b37b2db46b4171a8 |
| work_keys_str_mv |
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