The dynamics of human body weight change.

An imbalance between energy intake and energy expenditure will lead to a change in body weight (mass) and body composition (fat and lean masses). A quantitative understanding of the processes involved, which currently remains lacking, will be useful in determining the etiology and treatment of obesi...

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Autores principales:	Carson C Chow, Kevin D Hall
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9cfc121da06e4fbba059b1604d88b039
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id	oai:doaj.org-article:9cfc121da06e4fbba059b1604d88b039
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spelling	oai:doaj.org-article:9cfc121da06e4fbba059b1604d88b0392021-11-25T05:41:21ZThe dynamics of human body weight change.1553-734X1553-735810.1371/journal.pcbi.1000045https://doaj.org/article/9cfc121da06e4fbba059b1604d88b0392008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18369435/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358An imbalance between energy intake and energy expenditure will lead to a change in body weight (mass) and body composition (fat and lean masses). A quantitative understanding of the processes involved, which currently remains lacking, will be useful in determining the etiology and treatment of obesity and other conditions resulting from prolonged energy imbalance. Here, we show that a mathematical model of the macronutrient flux balances can capture the long-term dynamics of human weight change; all previous models are special cases of this model. We show that the generic dynamic behavior of body composition for a clamped diet can be divided into two classes. In the first class, the body composition and mass are determined uniquely. In the second class, the body composition can exist at an infinite number of possible states. Surprisingly, perturbations of dietary energy intake or energy expenditure can give identical responses in both model classes, and existing data are insufficient to distinguish between these two possibilities. Nevertheless, this distinction has important implications for the efficacy of clinical interventions that alter body composition and mass.Carson C ChowKevin D HallPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 4, Iss 3, p e1000045 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Carson C Chow Kevin D Hall The dynamics of human body weight change.
description	An imbalance between energy intake and energy expenditure will lead to a change in body weight (mass) and body composition (fat and lean masses). A quantitative understanding of the processes involved, which currently remains lacking, will be useful in determining the etiology and treatment of obesity and other conditions resulting from prolonged energy imbalance. Here, we show that a mathematical model of the macronutrient flux balances can capture the long-term dynamics of human weight change; all previous models are special cases of this model. We show that the generic dynamic behavior of body composition for a clamped diet can be divided into two classes. In the first class, the body composition and mass are determined uniquely. In the second class, the body composition can exist at an infinite number of possible states. Surprisingly, perturbations of dietary energy intake or energy expenditure can give identical responses in both model classes, and existing data are insufficient to distinguish between these two possibilities. Nevertheless, this distinction has important implications for the efficacy of clinical interventions that alter body composition and mass.
format	article
author	Carson C Chow Kevin D Hall
author_facet	Carson C Chow Kevin D Hall
author_sort	Carson C Chow
title	The dynamics of human body weight change.
title_short	The dynamics of human body weight change.
title_full	The dynamics of human body weight change.
title_fullStr	The dynamics of human body weight change.
title_full_unstemmed	The dynamics of human body weight change.
title_sort	dynamics of human body weight change.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/9cfc121da06e4fbba059b1604d88b039
work_keys_str_mv	AT carsoncchow thedynamicsofhumanbodyweightchange AT kevindhall thedynamicsofhumanbodyweightchange AT carsoncchow dynamicsofhumanbodyweightchange AT kevindhall dynamicsofhumanbodyweightchange
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The dynamics of human body weight change.

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