A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these...

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Autores principales: Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, Tannishtha Reya
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9cff1956974c4fd4bec74dfa1770589a
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spelling oai:doaj.org-article:9cff1956974c4fd4bec74dfa1770589a2021-12-02T15:39:27ZA stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia10.1038/s41467-020-19782-x2041-1723https://doaj.org/article/9cff1956974c4fd4bec74dfa1770589a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19782-xhttps://doaj.org/toc/2041-1723Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these aggressive, therapy resistant cells.Kyle SpinlerJeevisha BajajTakahiro ItoBryan ZimdahlMichael HamiltonArmin AhmadiClaire S. KoechleinNikki LytleHyog Young KwonFerdous Anower-E-KhudaHao SunAllen BlevinsJoi WeeksMarcie KritzikJan KarlsederMark H. GinsbergPyong Woo ParkJeffrey D. EskoTannishtha ReyaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kyle Spinler
Jeevisha Bajaj
Takahiro Ito
Bryan Zimdahl
Michael Hamilton
Armin Ahmadi
Claire S. Koechlein
Nikki Lytle
Hyog Young Kwon
Ferdous Anower-E-Khuda
Hao Sun
Allen Blevins
Joi Weeks
Marcie Kritzik
Jan Karlseder
Mark H. Ginsberg
Pyong Woo Park
Jeffrey D. Esko
Tannishtha Reya
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
description Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these aggressive, therapy resistant cells.
format article
author Kyle Spinler
Jeevisha Bajaj
Takahiro Ito
Bryan Zimdahl
Michael Hamilton
Armin Ahmadi
Claire S. Koechlein
Nikki Lytle
Hyog Young Kwon
Ferdous Anower-E-Khuda
Hao Sun
Allen Blevins
Joi Weeks
Marcie Kritzik
Jan Karlseder
Mark H. Ginsberg
Pyong Woo Park
Jeffrey D. Esko
Tannishtha Reya
author_facet Kyle Spinler
Jeevisha Bajaj
Takahiro Ito
Bryan Zimdahl
Michael Hamilton
Armin Ahmadi
Claire S. Koechlein
Nikki Lytle
Hyog Young Kwon
Ferdous Anower-E-Khuda
Hao Sun
Allen Blevins
Joi Weeks
Marcie Kritzik
Jan Karlseder
Mark H. Ginsberg
Pyong Woo Park
Jeffrey D. Esko
Tannishtha Reya
author_sort Kyle Spinler
title A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_short A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_full A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_fullStr A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_full_unstemmed A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_sort stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/9cff1956974c4fd4bec74dfa1770589a
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