mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose acts by inhibiting Akt, which normally suppresses...

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Autores principales: Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a
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spelling oai:doaj.org-article:9d01b8cdb7714197a5184f986c9a6f8a2021-12-02T14:42:37ZmTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases10.1038/ncomms143382041-1723https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14338https://doaj.org/toc/2041-1723The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose acts by inhibiting Akt, which normally suppresses TFEB via an mTORC1-independent mechanism.Michela PalmieriRituraj PalHemanth R. NelvagalParisa LotfiGary R. StinnettMichelle L. SeymourArindam ChaudhuryLakshya BajajVitaliy V. BondarLaura BremnerUsama SaleemDennis Y. TseDeepthi SanagasettiSamuel M. WuJoel R. NeilsonFred A. PereiraRobia G. PautlerGeorge G. RodneyJonathan D. CooperMarco SardielloNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michela Palmieri
Rituraj Pal
Hemanth R. Nelvagal
Parisa Lotfi
Gary R. Stinnett
Michelle L. Seymour
Arindam Chaudhury
Lakshya Bajaj
Vitaliy V. Bondar
Laura Bremner
Usama Saleem
Dennis Y. Tse
Deepthi Sanagasetti
Samuel M. Wu
Joel R. Neilson
Fred A. Pereira
Robia G. Pautler
George G. Rodney
Jonathan D. Cooper
Marco Sardiello
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
description The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose acts by inhibiting Akt, which normally suppresses TFEB via an mTORC1-independent mechanism.
format article
author Michela Palmieri
Rituraj Pal
Hemanth R. Nelvagal
Parisa Lotfi
Gary R. Stinnett
Michelle L. Seymour
Arindam Chaudhury
Lakshya Bajaj
Vitaliy V. Bondar
Laura Bremner
Usama Saleem
Dennis Y. Tse
Deepthi Sanagasetti
Samuel M. Wu
Joel R. Neilson
Fred A. Pereira
Robia G. Pautler
George G. Rodney
Jonathan D. Cooper
Marco Sardiello
author_facet Michela Palmieri
Rituraj Pal
Hemanth R. Nelvagal
Parisa Lotfi
Gary R. Stinnett
Michelle L. Seymour
Arindam Chaudhury
Lakshya Bajaj
Vitaliy V. Bondar
Laura Bremner
Usama Saleem
Dennis Y. Tse
Deepthi Sanagasetti
Samuel M. Wu
Joel R. Neilson
Fred A. Pereira
Robia G. Pautler
George G. Rodney
Jonathan D. Cooper
Marco Sardiello
author_sort Michela Palmieri
title mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
title_short mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
title_full mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
title_fullStr mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
title_full_unstemmed mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
title_sort mtorc1-independent tfeb activation via akt inhibition promotes cellular clearance in neurodegenerative storage diseases
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a
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