Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.

Radiologic images provide a way to monitor tumor development and its response to therapies in a longitudinal and minimally invasive fashion. However, they operate on a macroscopic scale (average value per voxel) and are not able to capture microscopic scale (cell-level) phenomena. Nevertheless, to e...

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Autores principales:	Jessica L Kingsley, James R Costello, Natarajan Raghunand, Katarzyna A Rejniak
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9d01d26f380147d1b97a378225982f6d
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spelling	oai:doaj.org-article:9d01d26f380147d1b97a378225982f6d2021-12-02T19:57:22ZBridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.1553-734X1553-735810.1371/journal.pcbi.1009206https://doaj.org/article/9d01d26f380147d1b97a378225982f6d2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009206https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Radiologic images provide a way to monitor tumor development and its response to therapies in a longitudinal and minimally invasive fashion. However, they operate on a macroscopic scale (average value per voxel) and are not able to capture microscopic scale (cell-level) phenomena. Nevertheless, to examine the causes of frequent fast fluctuations in tissue oxygenation, models simulating individual cells' behavior are needed. Here, we provide a link between the average data values recorded for radiologic images and the cellular and vascular architecture of the corresponding tissues. Using hybrid agent-based modeling, we generate a set of tissue morphologies capable of reproducing oxygenation levels observed in radiologic images. We then use these in silico tissues to investigate whether oxygen fluctuations can be explained by changes in vascular oxygen supply or by modulations in cellular oxygen absorption. Our studies show that intravascular changes in oxygen supply reproduce the observed fluctuations in tissue oxygenation in all considered regions of interest. However, larger-magnitude fluctuations cannot be recreated by modifications in cellular absorption of oxygen in a biologically feasible manner. Additionally, we develop a procedure to identify plausible tissue morphologies for a given temporal series of average data from radiology images. In future applications, this approach can be used to generate a set of tissues comparable with radiology images and to simulate tumor responses to various anti-cancer treatments at the tissue-scale level.Jessica L KingsleyJames R CostelloNatarajan RaghunandKatarzyna A RejniakPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009206 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jessica L Kingsley James R Costello Natarajan Raghunand Katarzyna A Rejniak Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.
description	Radiologic images provide a way to monitor tumor development and its response to therapies in a longitudinal and minimally invasive fashion. However, they operate on a macroscopic scale (average value per voxel) and are not able to capture microscopic scale (cell-level) phenomena. Nevertheless, to examine the causes of frequent fast fluctuations in tissue oxygenation, models simulating individual cells' behavior are needed. Here, we provide a link between the average data values recorded for radiologic images and the cellular and vascular architecture of the corresponding tissues. Using hybrid agent-based modeling, we generate a set of tissue morphologies capable of reproducing oxygenation levels observed in radiologic images. We then use these in silico tissues to investigate whether oxygen fluctuations can be explained by changes in vascular oxygen supply or by modulations in cellular oxygen absorption. Our studies show that intravascular changes in oxygen supply reproduce the observed fluctuations in tissue oxygenation in all considered regions of interest. However, larger-magnitude fluctuations cannot be recreated by modifications in cellular absorption of oxygen in a biologically feasible manner. Additionally, we develop a procedure to identify plausible tissue morphologies for a given temporal series of average data from radiology images. In future applications, this approach can be used to generate a set of tissues comparable with radiology images and to simulate tumor responses to various anti-cancer treatments at the tissue-scale level.
format	article
author	Jessica L Kingsley James R Costello Natarajan Raghunand Katarzyna A Rejniak
author_facet	Jessica L Kingsley James R Costello Natarajan Raghunand Katarzyna A Rejniak
author_sort	Jessica L Kingsley
title	Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.
title_short	Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.
title_full	Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.
title_fullStr	Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.
title_full_unstemmed	Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.
title_sort	bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9d01d26f380147d1b97a378225982f6d
work_keys_str_mv	AT jessicalkingsley bridgingcellscalesimulationsandradiologicimagestoexplainshorttimeintratumoraloxygenfluctuations AT jamesrcostello bridgingcellscalesimulationsandradiologicimagestoexplainshorttimeintratumoraloxygenfluctuations AT natarajanraghunand bridgingcellscalesimulationsandradiologicimagestoexplainshorttimeintratumoraloxygenfluctuations AT katarzynaarejniak bridgingcellscalesimulationsandradiologicimagestoexplainshorttimeintratumoraloxygenfluctuations
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Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.

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