A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq

A typical case of a 7-years-old Kurdish male shepherd dog was referred with two weeks history of lethargy, restlessness, anorexia and severe emaciation. Physical examination of the dog revealed generalized lymphadenopathy, strong pale mucous membrane, systolic murmur of the heart, vomiting, bloody d...

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Autores principales:	Shivan N. Hussein, Mohammed Sh. Shukur, Mariam I. Yassin, Ihsan K. Zangana
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2021
Materias:	bone marrow dog hematological disorder leukocytosis neoplasm Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2021.72493.1076 https://doaj.org/article/9d036b97d1c54f779540cddcfb2576b0
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spelling	oai:doaj.org-article:9d036b97d1c54f779540cddcfb2576b02021-12-02T15:32:49ZA Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraqhttps://dx.doi.org/10.21608/javs.2021.72493.10761687-40722090-3308https://doaj.org/article/9d036b97d1c54f779540cddcfb2576b02021-07-01T00:00:00Zhttps://javs.journals.ekb.eg/article_170491.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308A typical case of a 7-years-old Kurdish male shepherd dog was referred with two weeks history of lethargy, restlessness, anorexia and severe emaciation. Physical examination of the dog revealed generalized lymphadenopathy, strong pale mucous membrane, systolic murmur of the heart, vomiting, bloody diarrhea and fever. Hematological abnormalities indicated moderate to marked leukocytosis characterized by 89% neutrophilia with a left shift to progranulocytes and 1.6% presumptive myeloid blasts, marked thrombocytopenia, marked non-regenerative normocytic hypochromic anemia and dysplasia in platelets and neutrophils. The histopathological examination revealed excessive infiltration with neoplastic myeloid cells that invaded all the internal organs. Bone marrow analysis revealed marked hypercellularity with a predominance of immature cells, marked myeloid 6.2%, dysplasia of neutrophils lineage and rare erythroid progenitors and numerous megakaryocytes. Enlargement of superficial and visceral lymph nodes and internal body organs, especially liver and spleen were observed in the autopsy after animal euthanasia. Our results confirmed that this dog was suffering from chronic myeloid leukemia. Statistically, there was a significant difference (P < 0.05) between the mean value of myeloid blasts in peripheral blood and bone marrow. But, no significant difference (P > 0.05) was found between the mean values of leukocytic ratio in peripheral circulation and bone marrow. This is the first case report study that has been recorded in a native shepherd dog in a rural area around Duhok province/ Iraq. Shivan N. HusseinMohammed Sh. ShukurMariam I. YassinIhsan K. ZanganaEgyptian Society for Animal Managementarticlebone marrowdoghematological disorderleukocytosisneoplasmZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 6, Iss 3, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone marrow dog hematological disorder leukocytosis neoplasm Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	bone marrow dog hematological disorder leukocytosis neoplasm Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Shivan N. Hussein Mohammed Sh. Shukur Mariam I. Yassin Ihsan K. Zangana A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq
description	A typical case of a 7-years-old Kurdish male shepherd dog was referred with two weeks history of lethargy, restlessness, anorexia and severe emaciation. Physical examination of the dog revealed generalized lymphadenopathy, strong pale mucous membrane, systolic murmur of the heart, vomiting, bloody diarrhea and fever. Hematological abnormalities indicated moderate to marked leukocytosis characterized by 89% neutrophilia with a left shift to progranulocytes and 1.6% presumptive myeloid blasts, marked thrombocytopenia, marked non-regenerative normocytic hypochromic anemia and dysplasia in platelets and neutrophils. The histopathological examination revealed excessive infiltration with neoplastic myeloid cells that invaded all the internal organs. Bone marrow analysis revealed marked hypercellularity with a predominance of immature cells, marked myeloid 6.2%, dysplasia of neutrophils lineage and rare erythroid progenitors and numerous megakaryocytes. Enlargement of superficial and visceral lymph nodes and internal body organs, especially liver and spleen were observed in the autopsy after animal euthanasia. Our results confirmed that this dog was suffering from chronic myeloid leukemia. Statistically, there was a significant difference (P < 0.05) between the mean value of myeloid blasts in peripheral blood and bone marrow. But, no significant difference (P > 0.05) was found between the mean values of leukocytic ratio in peripheral circulation and bone marrow. This is the first case report study that has been recorded in a native shepherd dog in a rural area around Duhok province/ Iraq.
format	article
author	Shivan N. Hussein Mohammed Sh. Shukur Mariam I. Yassin Ihsan K. Zangana
author_facet	Shivan N. Hussein Mohammed Sh. Shukur Mariam I. Yassin Ihsan K. Zangana
author_sort	Shivan N. Hussein
title	A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq
title_short	A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq
title_full	A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq
title_fullStr	A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq
title_full_unstemmed	A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq
title_sort	typical case of chronic myeloid leukemia (cml) in a native shepherd dog in duhok province, iraq
publisher	Egyptian Society for Animal Management
publishDate	2021
url	https://dx.doi.org/10.21608/javs.2021.72493.1076 https://doaj.org/article/9d036b97d1c54f779540cddcfb2576b0
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A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq

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