Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats

Abstract Rice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague–Dawley rats fo...

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Autores principales:	Bahador Hajimohammadi, Gilda Eslami, Hengameh Zandi, Mohammad Hassan Ehrampoush, Azar Naimi, Maryam Derakhshan, Pegah Hedayat, Roozbeh Fallahi, Hossein Fallahzadeh, Mohammad Ebrahim Rezvani, Mahmoud Vakili, Seyed Mohammad Moshtaghioun, Seyyed Shamsadin Athari, Seyedeh Leili Asadi-Yousefabad, Saeedeh Sadat Hosseini, Mehrnoush Shirdeli, Salman Ahmadian, Shirin Mortazavi, Elahe Loni, Vahid Ajamein, Amin Ahmadi, Vahideh Askari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d03f5b4acea43ee84b76db25d8cd6df
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spelling	oai:doaj.org-article:9d03f5b4acea43ee84b76db25d8cd6df2021-12-02T15:23:03ZSafety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats10.1038/s41598-021-80958-62045-2322https://doaj.org/article/9d03f5b4acea43ee84b76db25d8cd6df2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-80958-6https://doaj.org/toc/2045-2322Abstract Rice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague–Dawley rats for 90 days. Totally, 120 rats in both sexes were used for three different diets, including 50% GM Bt rice, feeding with 50% rice, and standard feeding. Each 40 SD rats including 20 males and 20 females were considered as each diet. The clinical variables such as body weight and food consumption were measured and a range of clinical tests was examined, including hematology, serum chemistry parameters, urinalysis profile, thyroid, and sex hormone levels. Pathological assessments were also done. The results showed that the mean weekly feed utilization (%) had no significant difference among the studied groups. Also, blood biochemistry, hematological parameters, urine analysis, and hormonal levels had no significant differences among the groups. However, alanine aminotransferase was less in males versus female feeding with GM Bt rice. No histopathological changes were observed among the groups. In conclusion, this study demonstrated that GM Bt rice had no obvious adverse effects on rats' health.Bahador HajimohammadiGilda EslamiHengameh ZandiMohammad Hassan EhrampoushAzar NaimiMaryam DerakhshanPegah HedayatRoozbeh FallahiHossein FallahzadehMohammad Ebrahim RezvaniMahmoud VakiliSeyed Mohammad MoshtaghiounSeyyed Shamsadin AthariSeyedeh Leili Asadi-YousefabadSaeedeh Sadat HosseiniMehrnoush ShirdeliSalman AhmadianShirin MortazaviElahe LoniVahid AjameinAmin AhmadiVahideh AskariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bahador Hajimohammadi Gilda Eslami Hengameh Zandi Mohammad Hassan Ehrampoush Azar Naimi Maryam Derakhshan Pegah Hedayat Roozbeh Fallahi Hossein Fallahzadeh Mohammad Ebrahim Rezvani Mahmoud Vakili Seyed Mohammad Moshtaghioun Seyyed Shamsadin Athari Seyedeh Leili Asadi-Yousefabad Saeedeh Sadat Hosseini Mehrnoush Shirdeli Salman Ahmadian Shirin Mortazavi Elahe Loni Vahid Ajamein Amin Ahmadi Vahideh Askari Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
description	Abstract Rice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague–Dawley rats for 90 days. Totally, 120 rats in both sexes were used for three different diets, including 50% GM Bt rice, feeding with 50% rice, and standard feeding. Each 40 SD rats including 20 males and 20 females were considered as each diet. The clinical variables such as body weight and food consumption were measured and a range of clinical tests was examined, including hematology, serum chemistry parameters, urinalysis profile, thyroid, and sex hormone levels. Pathological assessments were also done. The results showed that the mean weekly feed utilization (%) had no significant difference among the studied groups. Also, blood biochemistry, hematological parameters, urine analysis, and hormonal levels had no significant differences among the groups. However, alanine aminotransferase was less in males versus female feeding with GM Bt rice. No histopathological changes were observed among the groups. In conclusion, this study demonstrated that GM Bt rice had no obvious adverse effects on rats' health.
format	article
author	Bahador Hajimohammadi Gilda Eslami Hengameh Zandi Mohammad Hassan Ehrampoush Azar Naimi Maryam Derakhshan Pegah Hedayat Roozbeh Fallahi Hossein Fallahzadeh Mohammad Ebrahim Rezvani Mahmoud Vakili Seyed Mohammad Moshtaghioun Seyyed Shamsadin Athari Seyedeh Leili Asadi-Yousefabad Saeedeh Sadat Hosseini Mehrnoush Shirdeli Salman Ahmadian Shirin Mortazavi Elahe Loni Vahid Ajamein Amin Ahmadi Vahideh Askari
author_facet	Bahador Hajimohammadi Gilda Eslami Hengameh Zandi Mohammad Hassan Ehrampoush Azar Naimi Maryam Derakhshan Pegah Hedayat Roozbeh Fallahi Hossein Fallahzadeh Mohammad Ebrahim Rezvani Mahmoud Vakili Seyed Mohammad Moshtaghioun Seyyed Shamsadin Athari Seyedeh Leili Asadi-Yousefabad Saeedeh Sadat Hosseini Mehrnoush Shirdeli Salman Ahmadian Shirin Mortazavi Elahe Loni Vahid Ajamein Amin Ahmadi Vahideh Askari
author_sort	Bahador Hajimohammadi
title	Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
title_short	Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
title_full	Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
title_fullStr	Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
title_full_unstemmed	Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats
title_sort	safety assessment of genetically modified rice expressing cry1ab protein in sprague–dawley rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9d03f5b4acea43ee84b76db25d8cd6df
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Safety assessment of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats

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