Immunological outcomes of exercise in older adults

David S Senchina1, Marian L Kohut21Biology Department, Drake University, Des Moines, IA, USA; 2Gerontology Program, Department of Health and Human Performance, Iowa State University, Ames, IA, USAAbstract: Aging is associated with a dysregulation of the immune system known as immunosenescence. Immun...

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Autores principales:	David S Senchina, Marian L Kohut
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9d09568a9e3f4aa5aca8defc90a3b23d
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spelling	oai:doaj.org-article:9d09568a9e3f4aa5aca8defc90a3b23d2021-12-02T05:07:03ZImmunological outcomes of exercise in older adults1178-1998https://doaj.org/article/9d09568a9e3f4aa5aca8defc90a3b23d2007-04-01T00:00:00Zhttps://www.dovepress.com/immunological-outcomes-of-exercise-in-older-adults-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998David S Senchina1, Marian L Kohut21Biology Department, Drake University, Des Moines, IA, USA; 2Gerontology Program, Department of Health and Human Performance, Iowa State University, Ames, IA, USAAbstract: Aging is associated with a dysregulation of the immune system known as immunosenescence. Immunosenescence involves cellular and molecular alterations that impact both innate and adaptive immunity, leading to increased incidences of infectious disease morbidity and mortality as well as heightened rates of other immune disorders such as autoimmunity, cancer, and inflammatory conditions. While current data suggests physical activity may be an effective and logistically easy strategy for counteracting immunosenescence, it is currently underutilized in clinical settings. Long-term, moderate physical activity interventions in geriatric populations appear to be associated with several benefits including reduction in infectious disease risk, increased rates of vaccine efficacy, and improvements in both physical and psychosocial aspects of daily living. Exercise may also represent a viable therapy in patients for whom pharmacological treatment is unavailable, ineffective, or inappropriate. The effects of exercise impact multiple aspects of immune response including T cell phenotype and proliferation, antibody response to vaccination, and cytokine production. However, an underlying mechanism by which exercise affects numerous cell types and responses remains to be identified. Given this evidence, an increase in the use of physical activity programs by the healthcare community may result in improved health of geriatric populations.Keywords: exercise, immunosenescenceDavid S SenchinaMarian L KohutDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 3-16 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 David S Senchina Marian L Kohut Immunological outcomes of exercise in older adults
description	David S Senchina1, Marian L Kohut21Biology Department, Drake University, Des Moines, IA, USA; 2Gerontology Program, Department of Health and Human Performance, Iowa State University, Ames, IA, USAAbstract: Aging is associated with a dysregulation of the immune system known as immunosenescence. Immunosenescence involves cellular and molecular alterations that impact both innate and adaptive immunity, leading to increased incidences of infectious disease morbidity and mortality as well as heightened rates of other immune disorders such as autoimmunity, cancer, and inflammatory conditions. While current data suggests physical activity may be an effective and logistically easy strategy for counteracting immunosenescence, it is currently underutilized in clinical settings. Long-term, moderate physical activity interventions in geriatric populations appear to be associated with several benefits including reduction in infectious disease risk, increased rates of vaccine efficacy, and improvements in both physical and psychosocial aspects of daily living. Exercise may also represent a viable therapy in patients for whom pharmacological treatment is unavailable, ineffective, or inappropriate. The effects of exercise impact multiple aspects of immune response including T cell phenotype and proliferation, antibody response to vaccination, and cytokine production. However, an underlying mechanism by which exercise affects numerous cell types and responses remains to be identified. Given this evidence, an increase in the use of physical activity programs by the healthcare community may result in improved health of geriatric populations.Keywords: exercise, immunosenescence
format	article
author	David S Senchina Marian L Kohut
author_facet	David S Senchina Marian L Kohut
author_sort	David S Senchina
title	Immunological outcomes of exercise in older adults
title_short	Immunological outcomes of exercise in older adults
title_full	Immunological outcomes of exercise in older adults
title_fullStr	Immunological outcomes of exercise in older adults
title_full_unstemmed	Immunological outcomes of exercise in older adults
title_sort	immunological outcomes of exercise in older adults
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/9d09568a9e3f4aa5aca8defc90a3b23d
work_keys_str_mv	AT davidssenchina immunologicaloutcomesofexerciseinolderadults AT marianlkohut immunologicaloutcomesofexerciseinolderadults
_version_	1718400608956841984

Immunological outcomes of exercise in older adults

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