Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study

Daniel Teshome Gebeyehu Department of Veterinary Medicine, School of Veterinary Medicine, Wollo University, Dessie, EthiopiaCorrespondence: Daniel Teshome Gebeyehu Email daniel.teshome@wu.edu.etBackground: In recent years, an increase in the development of antimicrobial-resistant pathogens especiall...

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Autor principal:	Gebeyehu DT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	food animals isolation salmonella antibiotics antibiotic resistance sheep Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/9d09f0b08726490bb5414a52620c4899
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spelling	oai:doaj.org-article:9d09f0b08726490bb5414a52620c48992021-12-02T15:55:56ZAntibiotic Resistance Development in Animal Production: A Cross-Sectional Study2230-2034https://doaj.org/article/9d09f0b08726490bb5414a52620c48992021-05-01T00:00:00Zhttps://www.dovepress.com/antibiotic-resistance-development-in-animal-production-a-cross-section-peer-reviewed-fulltext-article-VMRRhttps://doaj.org/toc/2230-2034Daniel Teshome Gebeyehu Department of Veterinary Medicine, School of Veterinary Medicine, Wollo University, Dessie, EthiopiaCorrespondence: Daniel Teshome Gebeyehu Email daniel.teshome@wu.edu.etBackground: In recent years, an increase in the development of antimicrobial-resistant pathogens especially foodborne zoonotic bacteria has been observed. As a result, crude mortality rates are increasing due to those resistant bacteria in both human and animal populations, particularly in developing countries like Tanzania where the risk of infection is high due to poor biosecurity measures, close animal–human interactions, and extensive use of antimicrobials for animal productions. One of those zoonotic bacterial pathogens, which commonly contaminates food, is Salmonella.Methodology: A cross-sectional study was carried out on samples collected from diarrheic sheep, to assess the level of antibiotic resistance of Salmonella. From 165 fecal samples, 80 of which were tested positive for Salmonella. The antibiotic resistance level of Salmonella isolates was conducted by the Kirby-Bauer disc diffusion method using ten commonly used antibiotics in the study area.Results: Out of 80 Salmonella positive samples, all (100%) of them were resistant to amoxicillin and ampicillin while sixty-eight (85%), 68 (85%), and 60 (75%) isolates were susceptible to gentamicin, ciprofloxacin, and kanamycin, respectively. Thirty (37.5%) Salmonella isolates were resistant to both trimethoprim and tetracycline and 25% of the isolates were resistant to both doxycycline and chloramphenicol while 12.5% of the isolates were resistant to nalidixic acid.Conclusion: This study revealed that the Salmonella isolates of diarrheic sheep developed a wide range of resistance to different antibiotics. Further studies and integrative approaches in a one health framework among animal–human and environmental health professionals are recommended for the mitigation of health risks arising from antibiotic-resistant zoonotic pathogens like Salmonella.Keywords: food animals, isolation, Salmonella, antibiotics, antibiotic resistance, sheepGebeyehu DTDove Medical Pressarticlefood animalsisolationsalmonellaantibioticsantibiotic resistancesheepVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 12, Pp 101-108 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	food animals isolation salmonella antibiotics antibiotic resistance sheep Veterinary medicine SF600-1100
spellingShingle	food animals isolation salmonella antibiotics antibiotic resistance sheep Veterinary medicine SF600-1100 Gebeyehu DT Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study
description	Daniel Teshome Gebeyehu Department of Veterinary Medicine, School of Veterinary Medicine, Wollo University, Dessie, EthiopiaCorrespondence: Daniel Teshome Gebeyehu Email daniel.teshome@wu.edu.etBackground: In recent years, an increase in the development of antimicrobial-resistant pathogens especially foodborne zoonotic bacteria has been observed. As a result, crude mortality rates are increasing due to those resistant bacteria in both human and animal populations, particularly in developing countries like Tanzania where the risk of infection is high due to poor biosecurity measures, close animal–human interactions, and extensive use of antimicrobials for animal productions. One of those zoonotic bacterial pathogens, which commonly contaminates food, is Salmonella.Methodology: A cross-sectional study was carried out on samples collected from diarrheic sheep, to assess the level of antibiotic resistance of Salmonella. From 165 fecal samples, 80 of which were tested positive for Salmonella. The antibiotic resistance level of Salmonella isolates was conducted by the Kirby-Bauer disc diffusion method using ten commonly used antibiotics in the study area.Results: Out of 80 Salmonella positive samples, all (100%) of them were resistant to amoxicillin and ampicillin while sixty-eight (85%), 68 (85%), and 60 (75%) isolates were susceptible to gentamicin, ciprofloxacin, and kanamycin, respectively. Thirty (37.5%) Salmonella isolates were resistant to both trimethoprim and tetracycline and 25% of the isolates were resistant to both doxycycline and chloramphenicol while 12.5% of the isolates were resistant to nalidixic acid.Conclusion: This study revealed that the Salmonella isolates of diarrheic sheep developed a wide range of resistance to different antibiotics. Further studies and integrative approaches in a one health framework among animal–human and environmental health professionals are recommended for the mitigation of health risks arising from antibiotic-resistant zoonotic pathogens like Salmonella.Keywords: food animals, isolation, Salmonella, antibiotics, antibiotic resistance, sheep
format	article
author	Gebeyehu DT
author_facet	Gebeyehu DT
author_sort	Gebeyehu DT
title	Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study
title_short	Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study
title_full	Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study
title_fullStr	Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study
title_full_unstemmed	Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study
title_sort	antibiotic resistance development in animal production: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9d09f0b08726490bb5414a52620c4899
work_keys_str_mv	AT gebeyehudt antibioticresistancedevelopmentinanimalproductionacrosssectionalstudy
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Antibiotic Resistance Development in Animal Production: A Cross-Sectional Study

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