Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.

<h4>Aims</h4>Biologics have been proven efficacious for patients with severe asthma (SA). It is essential to diagnose such individuals correctly. This study was designed to survey pulmonologists to identify barriers to early diagnosis and subsequent appropriate use of biologics for SA in...

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Autores principales:	Sanja Popović Grle, Marina Lampalo, Sanda Škrinjarić Cincar, Ljiljana Bulat Kardum, Ivan Gudelj, Eugenija Basioli Kasap, Mirna Vergles, Neven Tudorić
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d0c9f1f980e4b0cbb5a4cd87475f826
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spelling	oai:doaj.org-article:9d0c9f1f980e4b0cbb5a4cd87475f8262021-12-02T20:09:51ZAttitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.1932-620310.1371/journal.pone.0253468https://doaj.org/article/9d0c9f1f980e4b0cbb5a4cd87475f8262021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253468https://doaj.org/toc/1932-6203<h4>Aims</h4>Biologics have been proven efficacious for patients with severe asthma (SA). It is essential to diagnose such individuals correctly. This study was designed to survey pulmonologists to identify barriers to early diagnosis and subsequent appropriate use of biologics for SA in Croatia.<h4>Methods</h4>A pulmonologist group with expertise in SA developed the initial list of questions, with the final questionnaire created according to a 2-round Delphi method. The resulting survey consisted of 23 items consequently divided into 4 domains: 1) Pulmonologists' demographics and professional experiences; 2) Concerns about asthma management; 3) Attitudes toward SA diagnosis; and 4) Beliefs and attitudes regarding the use of biologics in managing SA. The given answers represented the respondents' estimates.<h4>Results</h4>Eighty-four surveys were analyzed, with pulmonologists observing that general practitioners often inaccurately diagnose asthma and treat acute exacerbations. Although specialist centers are capably and correctly equipped, the time to diagnose patients with SA is approximately 3.5 months, with initial use of biologics delayed an additional 2 months. The primary indications for prescribing biologics are conventional therapy with oral glucocorticoids (91.7%) and frequent acute exacerbations (82.1%). In addition to improper diagnosis (64.3%), many patients with SA do not receive the indicated biologics owing to strict administrative directives for reimbursement (70.2%) or limited hospital resources (57.1%).<h4>Limitations</h4>The limitations of this survey include the subjective nature of the collected data, the relatively small sample size, and the lack of the biologic efficacy evaluation.<h4>Conclusions</h4>Croatian pulmonologists observed that a significant number of patients with SA who are eligible for biologics are not prescribed them, largely because of an inaccurate and/or delayed diagnosis, a delayed referral to a specialist center, highly restrictive criteria for reimbursement, and/or institutional budgetary limitations.Sanja Popović GrleMarina LampaloSanda Škrinjarić CincarLjiljana Bulat KardumIvan GudeljEugenija Basioli KasapMirna VerglesNeven TudorićPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253468 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanja Popović Grle Marina Lampalo Sanda Škrinjarić Cincar Ljiljana Bulat Kardum Ivan Gudelj Eugenija Basioli Kasap Mirna Vergles Neven Tudorić Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.
description	<h4>Aims</h4>Biologics have been proven efficacious for patients with severe asthma (SA). It is essential to diagnose such individuals correctly. This study was designed to survey pulmonologists to identify barriers to early diagnosis and subsequent appropriate use of biologics for SA in Croatia.<h4>Methods</h4>A pulmonologist group with expertise in SA developed the initial list of questions, with the final questionnaire created according to a 2-round Delphi method. The resulting survey consisted of 23 items consequently divided into 4 domains: 1) Pulmonologists' demographics and professional experiences; 2) Concerns about asthma management; 3) Attitudes toward SA diagnosis; and 4) Beliefs and attitudes regarding the use of biologics in managing SA. The given answers represented the respondents' estimates.<h4>Results</h4>Eighty-four surveys were analyzed, with pulmonologists observing that general practitioners often inaccurately diagnose asthma and treat acute exacerbations. Although specialist centers are capably and correctly equipped, the time to diagnose patients with SA is approximately 3.5 months, with initial use of biologics delayed an additional 2 months. The primary indications for prescribing biologics are conventional therapy with oral glucocorticoids (91.7%) and frequent acute exacerbations (82.1%). In addition to improper diagnosis (64.3%), many patients with SA do not receive the indicated biologics owing to strict administrative directives for reimbursement (70.2%) or limited hospital resources (57.1%).<h4>Limitations</h4>The limitations of this survey include the subjective nature of the collected data, the relatively small sample size, and the lack of the biologic efficacy evaluation.<h4>Conclusions</h4>Croatian pulmonologists observed that a significant number of patients with SA who are eligible for biologics are not prescribed them, largely because of an inaccurate and/or delayed diagnosis, a delayed referral to a specialist center, highly restrictive criteria for reimbursement, and/or institutional budgetary limitations.
format	article
author	Sanja Popović Grle Marina Lampalo Sanda Škrinjarić Cincar Ljiljana Bulat Kardum Ivan Gudelj Eugenija Basioli Kasap Mirna Vergles Neven Tudorić
author_facet	Sanja Popović Grle Marina Lampalo Sanda Škrinjarić Cincar Ljiljana Bulat Kardum Ivan Gudelj Eugenija Basioli Kasap Mirna Vergles Neven Tudorić
author_sort	Sanja Popović Grle
title	Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.
title_short	Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.
title_full	Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.
title_fullStr	Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.
title_full_unstemmed	Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.
title_sort	attitudes of croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: survey results.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9d0c9f1f980e4b0cbb5a4cd87475f826
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Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results.

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