Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions

Large-scale deletions of mitochondrial DNA (mtDNA) are associated with different human mitochondrial diseases and normal human ageing. Here the authors present a model for mtDNA formation based on generation sequencing analysis of patients samples and in vitro reconstituted mtDNA deletion using puri...

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Autores principales:	Örjan Persson, Yazh Muthukumar, Swaraj Basu, Louise Jenninger, Jay P. Uhler, Anna-Karin Berglund, Robert McFarland, Robert W. Taylor, Claes M. Gustafsson, Erik Larsson, Maria Falkenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d0cf8b3b0044c29ad782cb60959b619
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spelling	oai:doaj.org-article:9d0cf8b3b0044c29ad782cb60959b6192021-12-02T14:38:36ZCopy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions10.1038/s41467-019-08673-52041-1723https://doaj.org/article/9d0cf8b3b0044c29ad782cb60959b6192019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08673-5https://doaj.org/toc/2041-1723Large-scale deletions of mitochondrial DNA (mtDNA) are associated with different human mitochondrial diseases and normal human ageing. Here the authors present a model for mtDNA formation based on generation sequencing analysis of patients samples and in vitro reconstituted mtDNA deletion using purified proteins.Örjan PerssonYazh MuthukumarSwaraj BasuLouise JenningerJay P. UhlerAnna-Karin BerglundRobert McFarlandRobert W. TaylorClaes M. GustafssonErik LarssonMaria FalkenbergNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Örjan Persson Yazh Muthukumar Swaraj Basu Louise Jenninger Jay P. Uhler Anna-Karin Berglund Robert McFarland Robert W. Taylor Claes M. Gustafsson Erik Larsson Maria Falkenberg Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
description	Large-scale deletions of mitochondrial DNA (mtDNA) are associated with different human mitochondrial diseases and normal human ageing. Here the authors present a model for mtDNA formation based on generation sequencing analysis of patients samples and in vitro reconstituted mtDNA deletion using purified proteins.
format	article
author	Örjan Persson Yazh Muthukumar Swaraj Basu Louise Jenninger Jay P. Uhler Anna-Karin Berglund Robert McFarland Robert W. Taylor Claes M. Gustafsson Erik Larsson Maria Falkenberg
author_facet	Örjan Persson Yazh Muthukumar Swaraj Basu Louise Jenninger Jay P. Uhler Anna-Karin Berglund Robert McFarland Robert W. Taylor Claes M. Gustafsson Erik Larsson Maria Falkenberg
author_sort	Örjan Persson
title	Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
title_short	Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
title_full	Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
title_fullStr	Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
title_full_unstemmed	Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
title_sort	copy-choice recombination during mitochondrial l-strand synthesis causes dna deletions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9d0cf8b3b0044c29ad782cb60959b619
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_version_	1718390967766089728

Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions

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