Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis

Trehalose metabolism has been linked to Mycobacterium tuberculosis (Mtb) virulence and biofilm formation. Here, using a model of drug-tolerant persisters and metabolomics, the authors dissect the role of trehalose metabolism in Mtb persister formation, linking trehalose-catalytic shift to antibiotic...

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Autores principales:	Jae Jin Lee, Sun-Kyung Lee, Naomi Song, Temitope O. Nathan, Benjamin M. Swarts, Seok-Yong Eum, Sabine Ehrt, Sang-Nae Cho, Hyungjin Eoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d0e0c7a56c743838cd2c25314a61d92
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spelling	oai:doaj.org-article:9d0e0c7a56c743838cd2c25314a61d922021-12-02T17:01:27ZTransient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis10.1038/s41467-019-10975-72041-1723https://doaj.org/article/9d0e0c7a56c743838cd2c25314a61d922019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10975-7https://doaj.org/toc/2041-1723Trehalose metabolism has been linked to Mycobacterium tuberculosis (Mtb) virulence and biofilm formation. Here, using a model of drug-tolerant persisters and metabolomics, the authors dissect the role of trehalose metabolism in Mtb persister formation, linking trehalose-catalytic shift to antibiotic resistance.Jae Jin LeeSun-Kyung LeeNaomi SongTemitope O. NathanBenjamin M. SwartsSeok-Yong EumSabine EhrtSang-Nae ChoHyungjin EohNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jae Jin Lee Sun-Kyung Lee Naomi Song Temitope O. Nathan Benjamin M. Swarts Seok-Yong Eum Sabine Ehrt Sang-Nae Cho Hyungjin Eoh Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
description	Trehalose metabolism has been linked to Mycobacterium tuberculosis (Mtb) virulence and biofilm formation. Here, using a model of drug-tolerant persisters and metabolomics, the authors dissect the role of trehalose metabolism in Mtb persister formation, linking trehalose-catalytic shift to antibiotic resistance.
format	article
author	Jae Jin Lee Sun-Kyung Lee Naomi Song Temitope O. Nathan Benjamin M. Swarts Seok-Yong Eum Sabine Ehrt Sang-Nae Cho Hyungjin Eoh
author_facet	Jae Jin Lee Sun-Kyung Lee Naomi Song Temitope O. Nathan Benjamin M. Swarts Seok-Yong Eum Sabine Ehrt Sang-Nae Cho Hyungjin Eoh
author_sort	Jae Jin Lee
title	Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
title_short	Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
title_full	Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
title_fullStr	Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
title_full_unstemmed	Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
title_sort	transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9d0e0c7a56c743838cd2c25314a61d92
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Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis

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