Pregnancy weight gain and childhood body weight: a within-family comparison.

<h4>Background</h4>Excessive pregnancy weight gain is associated with obesity in the offspring, but this relationship may be confounded by genetic and other shared influences. We aimed to examine the association of pregnancy weight gain with body mass index (BMI) in the offspring, using...

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Autores principales:	David S Ludwig, Heather L Rouse, Janet Currie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/9d11acbe15084495abbdc82d15f23a5e
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spelling	oai:doaj.org-article:9d11acbe15084495abbdc82d15f23a5e2021-11-18T05:43:08ZPregnancy weight gain and childhood body weight: a within-family comparison.1549-12771549-167610.1371/journal.pmed.1001521https://doaj.org/article/9d11acbe15084495abbdc82d15f23a5e2013-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130460/pdf/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676<h4>Background</h4>Excessive pregnancy weight gain is associated with obesity in the offspring, but this relationship may be confounded by genetic and other shared influences. We aimed to examine the association of pregnancy weight gain with body mass index (BMI) in the offspring, using a within-family design to minimize confounding.<h4>Methods and findings</h4>In this population-based cohort study, we matched records of all live births in Arkansas with state-mandated data on childhood BMI collected in public schools (from August 18, 2003 to June 2, 2011). The cohort included 42,133 women who had more than one singleton pregnancy and their 91,045 offspring. We examined how differences in weight gain that occurred during two or more pregnancies for each woman predicted her children's BMI and odds ratio (OR) of being overweight or obese (BMI≥85th percentile) at a mean age of 11.9 years, using a within-family design. For every additional kg of pregnancy weight gain, childhood BMI increased by 0.0220 (95% CI 0.0134-0.0306, p<0.0001) and the OR of overweight/obesity increased by 1.007 (CI 1.003-1.012, p = 0.0008). Variations in pregnancy weight gain accounted for a 0.43 kg/m(2) difference in childhood BMI. After adjustment for birth weight, the association of pregnancy weight gain with childhood BMI was attenuated but remained statistically significant (0.0143 kg/m(2) per kg of pregnancy weight gain, CI 0.0057-0.0229, p = 0.0007).<h4>Conclusions</h4>High pregnancy weight gain is associated with increased body weight of the offspring in childhood, and this effect is only partially mediated through higher birth weight. Translation of these findings to public health obesity prevention requires additional study. Please see later in the article for the Editors' Summary.David S LudwigHeather L RouseJanet CurriePublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 10, Iss 10, p e1001521 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R David S Ludwig Heather L Rouse Janet Currie Pregnancy weight gain and childhood body weight: a within-family comparison.
description	<h4>Background</h4>Excessive pregnancy weight gain is associated with obesity in the offspring, but this relationship may be confounded by genetic and other shared influences. We aimed to examine the association of pregnancy weight gain with body mass index (BMI) in the offspring, using a within-family design to minimize confounding.<h4>Methods and findings</h4>In this population-based cohort study, we matched records of all live births in Arkansas with state-mandated data on childhood BMI collected in public schools (from August 18, 2003 to June 2, 2011). The cohort included 42,133 women who had more than one singleton pregnancy and their 91,045 offspring. We examined how differences in weight gain that occurred during two or more pregnancies for each woman predicted her children's BMI and odds ratio (OR) of being overweight or obese (BMI≥85th percentile) at a mean age of 11.9 years, using a within-family design. For every additional kg of pregnancy weight gain, childhood BMI increased by 0.0220 (95% CI 0.0134-0.0306, p<0.0001) and the OR of overweight/obesity increased by 1.007 (CI 1.003-1.012, p = 0.0008). Variations in pregnancy weight gain accounted for a 0.43 kg/m(2) difference in childhood BMI. After adjustment for birth weight, the association of pregnancy weight gain with childhood BMI was attenuated but remained statistically significant (0.0143 kg/m(2) per kg of pregnancy weight gain, CI 0.0057-0.0229, p = 0.0007).<h4>Conclusions</h4>High pregnancy weight gain is associated with increased body weight of the offspring in childhood, and this effect is only partially mediated through higher birth weight. Translation of these findings to public health obesity prevention requires additional study. Please see later in the article for the Editors' Summary.
format	article
author	David S Ludwig Heather L Rouse Janet Currie
author_facet	David S Ludwig Heather L Rouse Janet Currie
author_sort	David S Ludwig
title	Pregnancy weight gain and childhood body weight: a within-family comparison.
title_short	Pregnancy weight gain and childhood body weight: a within-family comparison.
title_full	Pregnancy weight gain and childhood body weight: a within-family comparison.
title_fullStr	Pregnancy weight gain and childhood body weight: a within-family comparison.
title_full_unstemmed	Pregnancy weight gain and childhood body weight: a within-family comparison.
title_sort	pregnancy weight gain and childhood body weight: a within-family comparison.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9d11acbe15084495abbdc82d15f23a5e
work_keys_str_mv	AT davidsludwig pregnancyweightgainandchildhoodbodyweightawithinfamilycomparison AT heatherlrouse pregnancyweightgainandchildhoodbodyweightawithinfamilycomparison AT janetcurrie pregnancyweightgainandchildhoodbodyweightawithinfamilycomparison
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Pregnancy weight gain and childhood body weight: a within-family comparison.

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