Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats

Lindokuhle Patience Mabuza,1 Mlindeli Wilkinson Gamede,1 Sanam Maikoo,2 Irvin Noel Booysen,2 Phikelelani Siphosethu Ngubane,1 Andile Khathi1 1Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Afr...

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Autores principales:	Mabuza LP, Gamede MW, Maikoo S, Booysen IN, Ngubane PS, Khathi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Pre-diabetes Cardiovascular complications ruthenium dietary intervention Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9d159d3c2e8c44ecb890856527622630
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spelling	oai:doaj.org-article:9d159d3c2e8c44ecb8908565276226302021-12-02T05:07:58ZCardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats1178-7007https://doaj.org/article/9d159d3c2e8c44ecb8908565276226302019-02-01T00:00:00Zhttps://www.dovepress.com/cardioprotective-effects-of-a-ruthenium-ii-schiff-base-complex-in-diet-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lindokuhle Patience Mabuza,1 Mlindeli Wilkinson Gamede,1 Sanam Maikoo,2 Irvin Noel Booysen,2 Phikelelani Siphosethu Ngubane,1 Andile Khathi1 1Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; 2Department of Chemistry, School of Chemistry and Physics, College of Agricultural, Engineering and Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa Background: Prediabetes and the onset of cardiovascular diseases (CVD) are strongly related. Prolonged hyperglycemia has been identified as a major contributing factor in the pathogenesis of CVD and diabetic complications. The management of hyperglycemia and prediabetes-associated vascular complications rely on pharmacotherapy and lifestyle intervention strategies. However, patients still take the conventional drugs and neglect lifestyle intervention; therefore, newer alternative drugs are required. The synthesized ruthenium Schiff base complex has been shown to have elevated biological and antidiabetic activity. Thus, the research investigated the cardioprotective effects of ruthenium (II) Schiff base complex in diet-induced prediabetic (PD) rats. Materials and methods: The rats were randomly allocated to respective groups and treated for 12 weeks. Ruthenium (15 mg/kg) was administered to PD rats once a day every third day. Blood pressure and plasma glucose were monitored throughout the study. Blood and heart tissue were collected for biochemical assays. Results: Ruthenium complex with dietary intervention lead to reduced mean arterial blood pressure which correlated with a restored heart to body weight ratio. Additionally, there was a significant decrease in tissue malondialdehyde and increased superoxide dismutase and glutathione peroxidase concentration in both the plasma and heart tissue. Furthermore, there was a decrease in plasma triglycerides, low-density lipoprotein with an increased high-density lipoprotein concentration in ruthenium-treated rats. This was further evidenced by reduced plasma tumor necrosis factor-α, IL-6, and cardiac C-reactive protein concentrations in ruthenium-treated rats. Conclusion: Ruthenium coupled with dietary intervention decreased the risk of developing cardiac injury, thus preventing CVD in prediabetes. Therefore, this complex may be a beneficial therapeutic agent in the prevention of PD cardiovascular complications. Keywords: prediabetes, cardiovascular complications, ruthenium, dietary intervention, lipid profile, antioxidants, anti-inflammatoryMabuza LPGamede MWMaikoo SBooysen INNgubane PSKhathi ADove Medical PressarticlePre-diabetesCardiovascular complicationsrutheniumdietary interventionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 217-223 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pre-diabetes Cardiovascular complications ruthenium dietary intervention Specialties of internal medicine RC581-951
spellingShingle	Pre-diabetes Cardiovascular complications ruthenium dietary intervention Specialties of internal medicine RC581-951 Mabuza LP Gamede MW Maikoo S Booysen IN Ngubane PS Khathi A Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats
description	Lindokuhle Patience Mabuza,1 Mlindeli Wilkinson Gamede,1 Sanam Maikoo,2 Irvin Noel Booysen,2 Phikelelani Siphosethu Ngubane,1 Andile Khathi1 1Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; 2Department of Chemistry, School of Chemistry and Physics, College of Agricultural, Engineering and Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa Background: Prediabetes and the onset of cardiovascular diseases (CVD) are strongly related. Prolonged hyperglycemia has been identified as a major contributing factor in the pathogenesis of CVD and diabetic complications. The management of hyperglycemia and prediabetes-associated vascular complications rely on pharmacotherapy and lifestyle intervention strategies. However, patients still take the conventional drugs and neglect lifestyle intervention; therefore, newer alternative drugs are required. The synthesized ruthenium Schiff base complex has been shown to have elevated biological and antidiabetic activity. Thus, the research investigated the cardioprotective effects of ruthenium (II) Schiff base complex in diet-induced prediabetic (PD) rats. Materials and methods: The rats were randomly allocated to respective groups and treated for 12 weeks. Ruthenium (15 mg/kg) was administered to PD rats once a day every third day. Blood pressure and plasma glucose were monitored throughout the study. Blood and heart tissue were collected for biochemical assays. Results: Ruthenium complex with dietary intervention lead to reduced mean arterial blood pressure which correlated with a restored heart to body weight ratio. Additionally, there was a significant decrease in tissue malondialdehyde and increased superoxide dismutase and glutathione peroxidase concentration in both the plasma and heart tissue. Furthermore, there was a decrease in plasma triglycerides, low-density lipoprotein with an increased high-density lipoprotein concentration in ruthenium-treated rats. This was further evidenced by reduced plasma tumor necrosis factor-α, IL-6, and cardiac C-reactive protein concentrations in ruthenium-treated rats. Conclusion: Ruthenium coupled with dietary intervention decreased the risk of developing cardiac injury, thus preventing CVD in prediabetes. Therefore, this complex may be a beneficial therapeutic agent in the prevention of PD cardiovascular complications. Keywords: prediabetes, cardiovascular complications, ruthenium, dietary intervention, lipid profile, antioxidants, anti-inflammatory
format	article
author	Mabuza LP Gamede MW Maikoo S Booysen IN Ngubane PS Khathi A
author_facet	Mabuza LP Gamede MW Maikoo S Booysen IN Ngubane PS Khathi A
author_sort	Mabuza LP
title	Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats
title_short	Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats
title_full	Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats
title_fullStr	Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats
title_full_unstemmed	Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats
title_sort	cardioprotective effects of a ruthenium (ii) schiff base complex in diet-induced prediabetic rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9d159d3c2e8c44ecb890856527622630
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Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats

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