Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy

Crohn's disease (CD) may have some severe complications that pose an increasing health burden and negatively impact the quality of life. There are two major types - intestinal and extraintestinal complications, in which immune and non-immune mechanisms take place. We aimed to search for some as...

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Autores principales:	Velikova Tsvetelina, Miladinova R., Ivanova-Todorova E., Kyurkchiev D., Spasova Z.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	crohn’s disease complications fecal calprotectin fecal lactoferrin immunosuppressive drugs Medicine R
Acceso en línea:	https://doaj.org/article/9d15b7e8c7fe426494c1e08b28fe141a
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spelling	oai:doaj.org-article:9d15b7e8c7fe426494c1e08b28fe141a2021-12-02T19:11:32ZExtraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy0324-175010.2478/amb-2018-0003https://doaj.org/article/9d15b7e8c7fe426494c1e08b28fe141a2018-03-01T00:00:00Zhttps://doi.org/10.2478/amb-2018-0003https://doaj.org/toc/0324-1750Crohn's disease (CD) may have some severe complications that pose an increasing health burden and negatively impact the quality of life. There are two major types - intestinal and extraintestinal complications, in which immune and non-immune mechanisms take place. We aimed to search for some associations between specific extraintestinal manifestation and intestinal complications in CD patients with some clinicallaboratory findings, immunological markers, and the therapy administered. We examined retrospectively medical files of 26 patients with CD at mean age 42 ± 13 years, including the laboratory results. The immunological markers fecal calprotectin (FC) and fecal lactoferrin (FL) were assessed in frozen fecal samples of the chosen patients. Seventy-three percent of the investigated CD patients had some extraintestinal manifestation and/or intestinal complications, at least 13/26 had intestinal complications. All three patients with extraintestinal signs were positive for FC and 2/3 were positive for FL. We observed a higher serum level of CRP (24.49 mg/l vs. 3.13 mg/l, p = 0.010), slightly lowered serum level of hemoglobin (120 g/l vs. 145 g/l, p = 0.044) and about 2-fold lower iron level (7.23 μmol/l vs. 14.0 μmol/l, p = 0.019) in patients with intestinal complications compared to patients without complications, respectively. Four out of thirteen patients with intestinal complications were without immunosuppressive therapy at the time of our study, and nine out of thirteen - on immunosuppressive drugs. Routine laboratory and immunology testing could be beneficial for gastroenterologists in identifying patients at high risk for the development of complications and in the decision making for more aggressive therapy early after diagnosis.Velikova TsvetelinaMiladinova R.Ivanova-Todorova E.Kyurkchiev D.Spasova Z.Sciendoarticlecrohn’s diseasecomplicationsfecal calprotectinfecal lactoferrinimmunosuppressive drugsMedicineRENActa Medica Bulgarica, Vol 45, Iss 1, Pp 16-21 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	crohn’s disease complications fecal calprotectin fecal lactoferrin immunosuppressive drugs Medicine R
spellingShingle	crohn’s disease complications fecal calprotectin fecal lactoferrin immunosuppressive drugs Medicine R Velikova Tsvetelina Miladinova R. Ivanova-Todorova E. Kyurkchiev D. Spasova Z. Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy
description	Crohn's disease (CD) may have some severe complications that pose an increasing health burden and negatively impact the quality of life. There are two major types - intestinal and extraintestinal complications, in which immune and non-immune mechanisms take place. We aimed to search for some associations between specific extraintestinal manifestation and intestinal complications in CD patients with some clinicallaboratory findings, immunological markers, and the therapy administered. We examined retrospectively medical files of 26 patients with CD at mean age 42 ± 13 years, including the laboratory results. The immunological markers fecal calprotectin (FC) and fecal lactoferrin (FL) were assessed in frozen fecal samples of the chosen patients. Seventy-three percent of the investigated CD patients had some extraintestinal manifestation and/or intestinal complications, at least 13/26 had intestinal complications. All three patients with extraintestinal signs were positive for FC and 2/3 were positive for FL. We observed a higher serum level of CRP (24.49 mg/l vs. 3.13 mg/l, p = 0.010), slightly lowered serum level of hemoglobin (120 g/l vs. 145 g/l, p = 0.044) and about 2-fold lower iron level (7.23 μmol/l vs. 14.0 μmol/l, p = 0.019) in patients with intestinal complications compared to patients without complications, respectively. Four out of thirteen patients with intestinal complications were without immunosuppressive therapy at the time of our study, and nine out of thirteen - on immunosuppressive drugs. Routine laboratory and immunology testing could be beneficial for gastroenterologists in identifying patients at high risk for the development of complications and in the decision making for more aggressive therapy early after diagnosis.
format	article
author	Velikova Tsvetelina Miladinova R. Ivanova-Todorova E. Kyurkchiev D. Spasova Z.
author_facet	Velikova Tsvetelina Miladinova R. Ivanova-Todorova E. Kyurkchiev D. Spasova Z.
author_sort	Velikova Tsvetelina
title	Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy
title_short	Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy
title_full	Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy
title_fullStr	Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy
title_full_unstemmed	Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy
title_sort	extraintestinal manifestations and intestinal complications in patients with crohn's disease: associations with some clinico-laboratory findings, immunological markers and therapy
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/9d15b7e8c7fe426494c1e08b28fe141a
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Extraintestinal Manifestations and Intestinal Complications in Patients with Crohn's Disease: Associations with Some Clinico-Laboratory Findings, Immunological Markers and Therapy

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