Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence

Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and drug addiction. With regard to this, in this...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Krasteva M., Koycheva Y., Taseva T., Simeonova S.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	dna methylation gene expression mrna alcohol dependence drug dependence Medicine R
Acceso en línea:	https://doaj.org/article/9d169e4b4bd34e30be71c3c2e0023355
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9d169e4b4bd34e30be71c3c2e0023355
record_format	dspace
spelling	oai:doaj.org-article:9d169e4b4bd34e30be71c3c2e00233552021-12-02T14:29:39ZChanges in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence0324-175010.2478/amb-2020-0039https://doaj.org/article/9d169e4b4bd34e30be71c3c2e00233552020-11-01T00:00:00Zhttps://doi.org/10.2478/amb-2020-0039https://doaj.org/toc/0324-1750Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and drug addiction. With regard to this, in this study we analyzed the expression levels of genes involved in DNA methylation, including DNMT1, DNMT3a, MeCP2, MBD1, MBD2, MBD3 and MBD4, in blood samples of alcohol and drug dependent persons in comparison to healthy abstainers.Krasteva M.Koycheva Y.Taseva T.Simeonova S.Sciendoarticledna methylationgene expressionmrnaalcohol dependencedrug dependenceMedicineRENActa Medica Bulgarica, Vol 47, Iss 4, Pp 11-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dna methylation gene expression mrna alcohol dependence drug dependence Medicine R
spellingShingle	dna methylation gene expression mrna alcohol dependence drug dependence Medicine R Krasteva M. Koycheva Y. Taseva T. Simeonova S. Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
description	Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and drug addiction. With regard to this, in this study we analyzed the expression levels of genes involved in DNA methylation, including DNMT1, DNMT3a, MeCP2, MBD1, MBD2, MBD3 and MBD4, in blood samples of alcohol and drug dependent persons in comparison to healthy abstainers.
format	article
author	Krasteva M. Koycheva Y. Taseva T. Simeonova S.
author_facet	Krasteva M. Koycheva Y. Taseva T. Simeonova S.
author_sort	Krasteva M.
title	Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_short	Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_full	Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_fullStr	Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_full_unstemmed	Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_sort	changes in the expression of dna methylation related genes in leukocytes of persons with alcohol and drug dependence
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/9d169e4b4bd34e30be71c3c2e0023355
work_keys_str_mv	AT krastevam changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence AT koychevay changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence AT tasevat changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence AT simeonovas changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence
_version_	1718391208801206272

Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence

Ejemplares similares