Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia

Introduction. Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease among children of the first year of life, especially children born prematurely with extremely low and very low body weight. Material and methods. To estimate the number of children born alive in the Perm Territor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vladislav SEMERICOV, Elena ZUBOVA, Vera LOSCAREVA, Liudmila SOFRONOVA, Maria PERMIACOVA
Formato:	article
Lenguaje:	EN FR RO RU
Publicado:	Asociatia de Biosiguranta si Biosecuritate 2020
Materias:	pcv13 vaccine pneumococcal infertion bronchopulmonary dysplasia Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d16ce2fd88344db86c01d8fc77e6c8c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9d16ce2fd88344db86c01d8fc77e6c8c
record_format	dspace
spelling	oai:doaj.org-article:9d16ce2fd88344db86c01d8fc77e6c8c2021-12-02T18:21:12ZVaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia10.38045/ohrm.2020.1.052887-34582587-3466https://doaj.org/article/9d16ce2fd88344db86c01d8fc77e6c8c2020-03-01T00:00:00Zhttps://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/29/16https://doaj.org/toc/2887-3458https://doaj.org/toc/2587-3466Introduction. Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease among children of the first year of life, especially children born prematurely with extremely low and very low body weight. Material and methods. To estimate the number of children born alive in the Perm Territory between 2015 and 2017, official statistics data were used. Experimental epidemiological studies were used to assess safety, reactogenicity, immunogenic activity, and preventive efficacy of the Prevnar 13 vaccine when immunizing preterm infants with bronchopulmonary dysplasia under prospective controlled randomized clinical observation. Results. There were 29 premature infants with bronchopulmonary dysplasia under observation, the control group comprised 29 unvaccinated premature infants with BPD and 30 full-term infants. The PCV 13 vaccination of preterm infants with BPD established good tolerance, poor reactogenicity (17.2±0.57%), and vaccine tolerance like full-term infants (16.5±0.55%), high safety profile, high immunogenic properties (seroconversion – 93.1%, seroconversion factor – 5.5). Evaluation of immunogenic activity among children with BPD vaccinated with the PCV 13 vaccine revealed high immunological efficacy compared to unvaccinated healthy children. Conclusion. The need for vaccination of premature babies with BDL against pneumococcal infection has been scientifically substantiated. The study has confirmed safety, poor reactogenicity, high immunogenic activity, and preventive efficacy of the Prevenar 13 vaccine among premature babies with BDL under the conditions of the catamnesis department of the perinatal center within the follow-up monitoring of vaccinated infants over three years.Vladislav SEMERICOVElena ZUBOVAVera LOSCAREVALiudmila SOFRONOVAMaria PERMIACOVAAsociatia de Biosiguranta si Biosecuritatearticlepcv13 vaccinepneumococcal infertionbronchopulmonary dysplasiaMedicineRScienceQENFRRORUOne Health & Risk Management, Vol 1, Iss 1, Pp 27-35 (2020)
institution	DOAJ
collection	DOAJ
language	EN FR RO RU
topic	pcv13 vaccine pneumococcal infertion bronchopulmonary dysplasia Medicine R Science Q
spellingShingle	pcv13 vaccine pneumococcal infertion bronchopulmonary dysplasia Medicine R Science Q Vladislav SEMERICOV Elena ZUBOVA Vera LOSCAREVA Liudmila SOFRONOVA Maria PERMIACOVA Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia
description	Introduction. Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease among children of the first year of life, especially children born prematurely with extremely low and very low body weight. Material and methods. To estimate the number of children born alive in the Perm Territory between 2015 and 2017, official statistics data were used. Experimental epidemiological studies were used to assess safety, reactogenicity, immunogenic activity, and preventive efficacy of the Prevnar 13 vaccine when immunizing preterm infants with bronchopulmonary dysplasia under prospective controlled randomized clinical observation. Results. There were 29 premature infants with bronchopulmonary dysplasia under observation, the control group comprised 29 unvaccinated premature infants with BPD and 30 full-term infants. The PCV 13 vaccination of preterm infants with BPD established good tolerance, poor reactogenicity (17.2±0.57%), and vaccine tolerance like full-term infants (16.5±0.55%), high safety profile, high immunogenic properties (seroconversion – 93.1%, seroconversion factor – 5.5). Evaluation of immunogenic activity among children with BPD vaccinated with the PCV 13 vaccine revealed high immunological efficacy compared to unvaccinated healthy children. Conclusion. The need for vaccination of premature babies with BDL against pneumococcal infection has been scientifically substantiated. The study has confirmed safety, poor reactogenicity, high immunogenic activity, and preventive efficacy of the Prevenar 13 vaccine among premature babies with BDL under the conditions of the catamnesis department of the perinatal center within the follow-up monitoring of vaccinated infants over three years.
format	article
author	Vladislav SEMERICOV Elena ZUBOVA Vera LOSCAREVA Liudmila SOFRONOVA Maria PERMIACOVA
author_facet	Vladislav SEMERICOV Elena ZUBOVA Vera LOSCAREVA Liudmila SOFRONOVA Maria PERMIACOVA
author_sort	Vladislav SEMERICOV
title	Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia
title_short	Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia
title_full	Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia
title_fullStr	Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia
title_full_unstemmed	Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia
title_sort	vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia
publisher	Asociatia de Biosiguranta si Biosecuritate
publishDate	2020
url	https://doaj.org/article/9d16ce2fd88344db86c01d8fc77e6c8c
work_keys_str_mv	AT vladislavsemericov vaccineprophylaxisofpneumococcalinfectionamongprematureinfantswithbronchopulmonarydysplasia AT elenazubova vaccineprophylaxisofpneumococcalinfectionamongprematureinfantswithbronchopulmonarydysplasia AT veraloscareva vaccineprophylaxisofpneumococcalinfectionamongprematureinfantswithbronchopulmonarydysplasia AT liudmilasofronova vaccineprophylaxisofpneumococcalinfectionamongprematureinfantswithbronchopulmonarydysplasia AT mariapermiacova vaccineprophylaxisofpneumococcalinfectionamongprematureinfantswithbronchopulmonarydysplasia
_version_	1718378170753744896

Vaccine prophylaxis of pneumococcal infection among premature infants with bronchopulmonary dysplasia

Ejemplares similares