Allosteric cross-talk in chromatin can mediate drug-drug synergy

Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin adducts.

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Autores principales:	Zenita Adhireksan, Giulia Palermo, Tina Riedel, Zhujun Ma, Reyhan Muhammad, Ursula Rothlisberger, Paul J. Dyson, Curt A. Davey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d1b4c81d2d84ca2b30e46381f058d95
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spelling	oai:doaj.org-article:9d1b4c81d2d84ca2b30e46381f058d952021-12-02T14:40:35ZAllosteric cross-talk in chromatin can mediate drug-drug synergy10.1038/ncomms148602041-1723https://doaj.org/article/9d1b4c81d2d84ca2b30e46381f058d952017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14860https://doaj.org/toc/2041-1723Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin adducts.Zenita AdhireksanGiulia PalermoTina RiedelZhujun MaReyhan MuhammadUrsula RothlisbergerPaul J. DysonCurt A. DaveyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zenita Adhireksan Giulia Palermo Tina Riedel Zhujun Ma Reyhan Muhammad Ursula Rothlisberger Paul J. Dyson Curt A. Davey Allosteric cross-talk in chromatin can mediate drug-drug synergy
description	Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin adducts.
format	article
author	Zenita Adhireksan Giulia Palermo Tina Riedel Zhujun Ma Reyhan Muhammad Ursula Rothlisberger Paul J. Dyson Curt A. Davey
author_facet	Zenita Adhireksan Giulia Palermo Tina Riedel Zhujun Ma Reyhan Muhammad Ursula Rothlisberger Paul J. Dyson Curt A. Davey
author_sort	Zenita Adhireksan
title	Allosteric cross-talk in chromatin can mediate drug-drug synergy
title_short	Allosteric cross-talk in chromatin can mediate drug-drug synergy
title_full	Allosteric cross-talk in chromatin can mediate drug-drug synergy
title_fullStr	Allosteric cross-talk in chromatin can mediate drug-drug synergy
title_full_unstemmed	Allosteric cross-talk in chromatin can mediate drug-drug synergy
title_sort	allosteric cross-talk in chromatin can mediate drug-drug synergy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9d1b4c81d2d84ca2b30e46381f058d95
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Allosteric cross-talk in chromatin can mediate drug-drug synergy

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