Of mice, cattle, and humans: the immunology and treatment of river blindness.

River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some pri...

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Autores principales:	Judith E Allen, Ohene Adjei, Odile Bain, Achim Hoerauf, Wolfgang H Hoffmann, Benjamin L Makepeace, Hartwig Schulz-Key, Vincent N Tanya, Alexander J Trees, Samuel Wanji, David W Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e
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spelling	oai:doaj.org-article:9d1f33605a1b4e62a09a3c957b063a9e2021-12-02T20:23:55ZOf mice, cattle, and humans: the immunology and treatment of river blindness.1935-27271935-273510.1371/journal.pntd.0000217https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e2008-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18446236/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease.Judith E AllenOhene AdjeiOdile BainAchim HoeraufWolfgang H HoffmannBenjamin L MakepeaceHartwig Schulz-KeyVincent N TanyaAlexander J TreesSamuel WanjiDavid W TaylorPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 2, Iss 4, p e217 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor Of mice, cattle, and humans: the immunology and treatment of river blindness.
description	River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease.
format	article
author	Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor
author_facet	Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor
author_sort	Judith E Allen
title	Of mice, cattle, and humans: the immunology and treatment of river blindness.
title_short	Of mice, cattle, and humans: the immunology and treatment of river blindness.
title_full	Of mice, cattle, and humans: the immunology and treatment of river blindness.
title_fullStr	Of mice, cattle, and humans: the immunology and treatment of river blindness.
title_full_unstemmed	Of mice, cattle, and humans: the immunology and treatment of river blindness.
title_sort	of mice, cattle, and humans: the immunology and treatment of river blindness.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e
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Of mice, cattle, and humans: the immunology and treatment of river blindness.

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