Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro

Exposure to metallic nanoparticles (NPs) can result in inadvertent NP accumulation in body tissues. While their subsequent cellular interactions can lead to unintended consequences and are generally regarded as detrimental for health, they can on occasion mediate biologically beneficial effects. Amo...

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Autores principales:	Adrian Boey, Shu Qing Leong, Sayali Bhave, Han Kiat Ho
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	liver fibrosis cerium oxide nanoparticles nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9d21766f4ce9415384dcbe756e4f3cbf
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spelling	oai:doaj.org-article:9d21766f4ce9415384dcbe756e4f3cbf2021-11-11T17:13:43ZCerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro10.3390/ijms2221117771422-00671661-6596https://doaj.org/article/9d21766f4ce9415384dcbe756e4f3cbf2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11777https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Exposure to metallic nanoparticles (NPs) can result in inadvertent NP accumulation in body tissues. While their subsequent cellular interactions can lead to unintended consequences and are generally regarded as detrimental for health, they can on occasion mediate biologically beneficial effects. Among NPs, cerium oxide nanoparticles (CeO<sub>2</sub> NP) possess strong antioxidant properties and have shown to alleviate certain pathological conditions. Herein, we show that the presence of cubic 25 nm CeO<sub>2</sub> NP was able to reduce TGF-β-mediated activation in the cultured hepatic stellate cell line LX2 by reducing oxidative stress levels and TGF-β-mediated signalling. These cells displayed reduced classical liver fibrosis phenotypes, such as diminished fibrogenesis, altered matrix degradation, decreased cell motility, modified contractability and potentially lowered autophagy. These findings demonstrate that CeO<sub>2</sub> NP may be able to ameliorate hepatic fibrosis and suggest a possible therapeutic pathway for an otherwise difficult-to-treat condition.Adrian BoeyShu Qing LeongSayali BhaveHan Kiat HoMDPI AGarticleliver fibrosiscerium oxide nanoparticlesnanoparticlesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11777, p 11777 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver fibrosis cerium oxide nanoparticles nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	liver fibrosis cerium oxide nanoparticles nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999 Adrian Boey Shu Qing Leong Sayali Bhave Han Kiat Ho Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
description	Exposure to metallic nanoparticles (NPs) can result in inadvertent NP accumulation in body tissues. While their subsequent cellular interactions can lead to unintended consequences and are generally regarded as detrimental for health, they can on occasion mediate biologically beneficial effects. Among NPs, cerium oxide nanoparticles (CeO<sub>2</sub> NP) possess strong antioxidant properties and have shown to alleviate certain pathological conditions. Herein, we show that the presence of cubic 25 nm CeO<sub>2</sub> NP was able to reduce TGF-β-mediated activation in the cultured hepatic stellate cell line LX2 by reducing oxidative stress levels and TGF-β-mediated signalling. These cells displayed reduced classical liver fibrosis phenotypes, such as diminished fibrogenesis, altered matrix degradation, decreased cell motility, modified contractability and potentially lowered autophagy. These findings demonstrate that CeO<sub>2</sub> NP may be able to ameliorate hepatic fibrosis and suggest a possible therapeutic pathway for an otherwise difficult-to-treat condition.
format	article
author	Adrian Boey Shu Qing Leong Sayali Bhave Han Kiat Ho
author_facet	Adrian Boey Shu Qing Leong Sayali Bhave Han Kiat Ho
author_sort	Adrian Boey
title	Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
title_short	Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
title_full	Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
title_fullStr	Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
title_full_unstemmed	Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro
title_sort	cerium oxide nanoparticles alleviate hepatic fibrosis phenotypes in vitro
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9d21766f4ce9415384dcbe756e4f3cbf
work_keys_str_mv	AT adrianboey ceriumoxidenanoparticlesalleviatehepaticfibrosisphenotypesinvitro AT shuqingleong ceriumoxidenanoparticlesalleviatehepaticfibrosisphenotypesinvitro AT sayalibhave ceriumoxidenanoparticlesalleviatehepaticfibrosisphenotypesinvitro AT hankiatho ceriumoxidenanoparticlesalleviatehepaticfibrosisphenotypesinvitro
_version_	1718432134870335488

Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro

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