NusG-Dependent RNA Polymerase Pausing and Tylosin-Dependent Ribosome Stalling Are Required for Tylosin Resistance by Inducing 23S rRNA Methylation in <named-content content-type="genus-species">Bacillus subtilis</named-content>

NusG-Dependent RNA Polymerase Pausing and Tylosin-Dependent Ribosome Stalling Are Required for Tylosin Resistance by Inducing 23S rRNA Methylation in <named-content content-type="genus-species">Bacillus subtilis</named-content>

ABSTRACT Macrolide antibiotics bind to 23S rRNA within the peptide exit tunnel of the ribosome, causing the translating ribosome to stall when an appropriately positioned macrolide arrest motif is encountered in the nascent polypeptide. Tylosin is a macrolide antibiotic produced by Streptomyces frad...

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Bibliographic Details
Main Authors: Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
NusG-dependent RNA polymerase pausing
transcription attenuation
antibiotic resistance
rRNA methylation
Microbiology
QR1-502
Online Access:https://doaj.org/article/9d25a70e7bc14faa966d3a8d0b96310c
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