Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery

Jianfeng Liu, Jinjian Liu, Hongyan Xu, Yumin Zhang, Liping Chu, Qingfen Liu, Naling Song, Cuihong YangTianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, People's Republic of ChinaAbstrac...

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Autores principales:	Liu J, Xu H, Zhang Y, Chu L, Liu Q, Song N, Yang C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9d2b48646b6c4837a77c18f44a26c8fa
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spelling	oai:doaj.org-article:9d2b48646b6c4837a77c18f44a26c8fa2021-12-02T02:14:37ZNovel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery1178-2013https://doaj.org/article/9d2b48646b6c4837a77c18f44a26c8fa2013-12-01T00:00:00Zhttp://www.dovepress.com/novel-tumor-targeting-self-assembling-peptide-nanofiber-as-a-carrier-f-a15367https://doaj.org/toc/1178-2013 Jianfeng Liu, Jinjian Liu, Hongyan Xu, Yumin Zhang, Liping Chu, Qingfen Liu, Naling Song, Cuihong YangTianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, People's Republic of ChinaAbstract: The poor aqueous solubility and low bioavailability of curcumin restrict its clinical application for cancer treatment. In this study, a novel tumor-targeting nanofiber carrier was developed to improve the solubility and tumor-targeting ability of curcumin using a self-assembled Nap-GFFYG-RGD peptide. The morphologies of the peptide nanofiber and the curcumin-encapsulated nanofiber were visualized by transmission electron microscopy. The tumor-targeting activity of the curcumin-encapsulated Nap-GFFYG-RGD peptide nanofiber (f-RGD-Cur) was studied in vitro and in vivo, using Nap-GFFYG-RGE peptide nanofiber (f-RGE-Cur) as the control. Curcumin was encapsulated into the peptide nanofiber, which had a diameter of approximately 10–20 nm. Curcumin showed sustained-release behavior from the nanofibers in vitro. f-RGD-Cur showed much higher cellular uptake in αvβ3 integrin-positive HepG2 liver carcinoma cells than did non-targeted f-RGE-Cur, thereby leading to significantly higher cytotoxicity. Ex vivo studies further demonstrated that curcumin could accumulate markedly in mouse tumors after administration of f-RGD-Cur via the tail vein. These results indicate that Nap-GFFYG-RGD peptide self-assembled nanofibers are a promising hydrophobic drug delivery system for targeted treatment of cancer.Keywords: nanofiber, tumor-targeting, self-assembling, curcumin, drug deliveryLiu JLiu JXu HZhang YChu LLiu QSong NYang CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 197-207 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Liu J Liu J Xu H Zhang Y Chu L Liu Q Song N Yang C Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery
description	Jianfeng Liu, Jinjian Liu, Hongyan Xu, Yumin Zhang, Liping Chu, Qingfen Liu, Naling Song, Cuihong YangTianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, People's Republic of ChinaAbstract: The poor aqueous solubility and low bioavailability of curcumin restrict its clinical application for cancer treatment. In this study, a novel tumor-targeting nanofiber carrier was developed to improve the solubility and tumor-targeting ability of curcumin using a self-assembled Nap-GFFYG-RGD peptide. The morphologies of the peptide nanofiber and the curcumin-encapsulated nanofiber were visualized by transmission electron microscopy. The tumor-targeting activity of the curcumin-encapsulated Nap-GFFYG-RGD peptide nanofiber (f-RGD-Cur) was studied in vitro and in vivo, using Nap-GFFYG-RGE peptide nanofiber (f-RGE-Cur) as the control. Curcumin was encapsulated into the peptide nanofiber, which had a diameter of approximately 10–20 nm. Curcumin showed sustained-release behavior from the nanofibers in vitro. f-RGD-Cur showed much higher cellular uptake in αvβ3 integrin-positive HepG2 liver carcinoma cells than did non-targeted f-RGE-Cur, thereby leading to significantly higher cytotoxicity. Ex vivo studies further demonstrated that curcumin could accumulate markedly in mouse tumors after administration of f-RGD-Cur via the tail vein. These results indicate that Nap-GFFYG-RGD peptide self-assembled nanofibers are a promising hydrophobic drug delivery system for targeted treatment of cancer.Keywords: nanofiber, tumor-targeting, self-assembling, curcumin, drug delivery
format	article
author	Liu J Liu J Xu H Zhang Y Chu L Liu Q Song N Yang C
author_facet	Liu J Liu J Xu H Zhang Y Chu L Liu Q Song N Yang C
author_sort	Liu J
title	Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery
title_short	Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery
title_full	Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery
title_fullStr	Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery
title_full_unstemmed	Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery
title_sort	novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/9d2b48646b6c4837a77c18f44a26c8fa
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Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery

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