Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction

Hideaki Okawada, Yuta Saito, Shigehiro Iwabuchi, Shotaro Kosuge, Haruo Takahashi, Hidetoshi Onda, Masahiro Kito Department of Ophthalmology, Showa University, Tokyo, Japan Purpose: Vascular endothelial growth factor (VEGF) plays an important role in branch retinal vein occlusion (BRVO) with cystoi...

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Autores principales:	Okawada H, Saito Y, Iwabuchi S, Kosuge S, Takahashi H, Onda H, Kito M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	aqueous humor branch retinal vein occlusion Flare protein density ranibizumab vascular endothelial growth factor Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9d2da8eba9c14cb08353faa152af16b9
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spelling	oai:doaj.org-article:9d2da8eba9c14cb08353faa152af16b92021-12-02T00:33:52ZRelationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction1177-5483https://doaj.org/article/9d2da8eba9c14cb08353faa152af16b92018-08-01T00:00:00Zhttps://www.dovepress.com/relationship-between-vascular-endothelial-growth-factor-and-macular-ed-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hideaki Okawada, Yuta Saito, Shigehiro Iwabuchi, Shotaro Kosuge, Haruo Takahashi, Hidetoshi Onda, Masahiro Kito Department of Ophthalmology, Showa University, Tokyo, Japan Purpose: Vascular endothelial growth factor (VEGF) plays an important role in branch retinal vein occlusion (BRVO) with cystoid macular edema (CME). Monitoring changes in VEGF is crucial for evaluating treatment but requires vitreous or aqueous humor sampling, which hampers its clinical application. We investigated the correlation between VEGF and protein concentration in the aqueous humor (flare) and whether this could be used to monitor treatment-related VEGF changes. Design: This retrospective observational study involved 19 previously untreated patients with BRVO. Aqueous humor was obtained, and intravitreal ranibizumab (IVR) injection was administered to these patients. The correlation between VEGF and flare, central retinal thickness (CRT), and best-corrected visual acuity (BCVA) was investigated. Differences in these values were considered between pre-IVR and 1 week and 1–3 months post-IVR. Moreover, in patients with recurrence who received additional IVR, further changes in VEGF were examined. Main outcome measures: The end point of this study was BCVA, flare, and CRT at the fovea. Results: Significant improvement was seen in BCVA and CRT at all time points and in Flare at 1 vs 3 months post-IVR; nevertheless, additional IVR was necessary in 94% of cases. In a patient with recurrence, CRT did not improve, even though VEGF decreased. Conclusion: Flare may be effective for estimating VEGF levels in aqueous humor pre-IVR. Inflammation-related molecules other than VEGF may be related to recurrence. Keywords: aqueous humor, branch retinal vein occlusion, flare, protein density, ranibizumab, vascular endothelial growth factorOkawada HSaito YIwabuchi SKosuge STakahashi HOnda HKito MDove Medical Pressarticleaqueous humorbranch retinal vein occlusionFlareprotein densityranibizumabvascular endothelial growth factorOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1379-1382 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	aqueous humor branch retinal vein occlusion Flare protein density ranibizumab vascular endothelial growth factor Ophthalmology RE1-994
spellingShingle	aqueous humor branch retinal vein occlusion Flare protein density ranibizumab vascular endothelial growth factor Ophthalmology RE1-994 Okawada H Saito Y Iwabuchi S Kosuge S Takahashi H Onda H Kito M Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction
description	Hideaki Okawada, Yuta Saito, Shigehiro Iwabuchi, Shotaro Kosuge, Haruo Takahashi, Hidetoshi Onda, Masahiro Kito Department of Ophthalmology, Showa University, Tokyo, Japan Purpose: Vascular endothelial growth factor (VEGF) plays an important role in branch retinal vein occlusion (BRVO) with cystoid macular edema (CME). Monitoring changes in VEGF is crucial for evaluating treatment but requires vitreous or aqueous humor sampling, which hampers its clinical application. We investigated the correlation between VEGF and protein concentration in the aqueous humor (flare) and whether this could be used to monitor treatment-related VEGF changes. Design: This retrospective observational study involved 19 previously untreated patients with BRVO. Aqueous humor was obtained, and intravitreal ranibizumab (IVR) injection was administered to these patients. The correlation between VEGF and flare, central retinal thickness (CRT), and best-corrected visual acuity (BCVA) was investigated. Differences in these values were considered between pre-IVR and 1 week and 1–3 months post-IVR. Moreover, in patients with recurrence who received additional IVR, further changes in VEGF were examined. Main outcome measures: The end point of this study was BCVA, flare, and CRT at the fovea. Results: Significant improvement was seen in BCVA and CRT at all time points and in Flare at 1 vs 3 months post-IVR; nevertheless, additional IVR was necessary in 94% of cases. In a patient with recurrence, CRT did not improve, even though VEGF decreased. Conclusion: Flare may be effective for estimating VEGF levels in aqueous humor pre-IVR. Inflammation-related molecules other than VEGF may be related to recurrence. Keywords: aqueous humor, branch retinal vein occlusion, flare, protein density, ranibizumab, vascular endothelial growth factor
format	article
author	Okawada H Saito Y Iwabuchi S Kosuge S Takahashi H Onda H Kito M
author_facet	Okawada H Saito Y Iwabuchi S Kosuge S Takahashi H Onda H Kito M
author_sort	Okawada H
title	Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction
title_short	Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction
title_full	Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction
title_fullStr	Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction
title_full_unstemmed	Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction
title_sort	relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9d2da8eba9c14cb08353faa152af16b9
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Relationship between vascular endothelial growth factor and macular edema in retinal vein branch obstruction

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