Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination

Iron gall chelate (GA-Fe) can promote oxygen reduction reactions and reactive oxygen species generation which causes chemical corrosion. Here, the authors, inspired by this phenomenon, develop a composite nanomedicine for tumour therapy constructed by loading gallate into Fe-engineered and PEGylated...

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Autores principales:	Bowen Yang, Heliang Yao, Han Tian, Zhiguo Yu, Yuedong Guo, Yuemei Wang, Jiacai Yang, Chang Chen, Jianlin Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d2fc84ecc24426dbc0d0dc1e1967ff7
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spelling	oai:doaj.org-article:9d2fc84ecc24426dbc0d0dc1e1967ff72021-12-02T18:06:25ZIntratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination10.1038/s41467-021-23710-y2041-1723https://doaj.org/article/9d2fc84ecc24426dbc0d0dc1e1967ff72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23710-yhttps://doaj.org/toc/2041-1723Iron gall chelate (GA-Fe) can promote oxygen reduction reactions and reactive oxygen species generation which causes chemical corrosion. Here, the authors, inspired by this phenomenon, develop a composite nanomedicine for tumour therapy constructed by loading gallate into Fe-engineered and PEGylated mesoporous silica nanocarrier, and show that it inhibits tumour growth.Bowen YangHeliang YaoHan TianZhiguo YuYuedong GuoYuemei WangJiacai YangChang ChenJianlin ShiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bowen Yang Heliang Yao Han Tian Zhiguo Yu Yuedong Guo Yuemei Wang Jiacai Yang Chang Chen Jianlin Shi Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
description	Iron gall chelate (GA-Fe) can promote oxygen reduction reactions and reactive oxygen species generation which causes chemical corrosion. Here, the authors, inspired by this phenomenon, develop a composite nanomedicine for tumour therapy constructed by loading gallate into Fe-engineered and PEGylated mesoporous silica nanocarrier, and show that it inhibits tumour growth.
format	article
author	Bowen Yang Heliang Yao Han Tian Zhiguo Yu Yuedong Guo Yuemei Wang Jiacai Yang Chang Chen Jianlin Shi
author_facet	Bowen Yang Heliang Yao Han Tian Zhiguo Yu Yuedong Guo Yuemei Wang Jiacai Yang Chang Chen Jianlin Shi
author_sort	Bowen Yang
title	Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
title_short	Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
title_full	Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
title_fullStr	Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
title_full_unstemmed	Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
title_sort	intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9d2fc84ecc24426dbc0d0dc1e1967ff7
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Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination

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