Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study

Abstract Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up is yet to be assessed. We investigated changes in connectivity in 16 severely obese women one month before,...

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Autores principales:	Gaia Olivo, Wei Zhou, Magnus Sundbom, Christina Zhukovsky, Pleunie Hogenkamp, Lamia Nikontovic, Julia Stark, Lyle Wiemerslage, Elna-Marie Larsson, Christian Benedict, Helgi B. Schiöth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d308f03b1064febbf339dec0d887bd3
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spelling	oai:doaj.org-article:9d308f03b1064febbf339dec0d887bd32021-12-02T12:32:28ZResting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study10.1038/s41598-017-06663-52045-2322https://doaj.org/article/9d308f03b1064febbf339dec0d887bd32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06663-5https://doaj.org/toc/2045-2322Abstract Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up is yet to be assessed. We investigated changes in connectivity in 16 severely obese women one month before, one month after and one year after Roux-en-Y gastric bypass surgery (RYGB). 12 lean controls were also enrolled. Resting-state fMRI was acquired for all participants following an overnight fast and after a 260 kcal load. Connectivity between regions involved in food-related saliency attribution and reward-driven eating behavior was stronger in presurgery patients compared to controls, but progressively weakened after follow-up. At one year, changes in networks related to cognitive control over eating and bodily perception also occurred. Connectivity between regions involved in emotional control and social cognition had a temporary reduction early after treatment but had increased again after one year of follow-up. Furthermore, we could predict the BMI loss by presurgery connectivity in areas linked to emotional control and social interaction. RYGBP seems to reshape brain functional connectivity, early affecting cognitive control over eating, and these changes could be an important part of the therapeutic effect of bariatric surgery.Gaia OlivoWei ZhouMagnus SundbomChristina ZhukovskyPleunie HogenkampLamia NikontovicJulia StarkLyle WiemerslageElna-Marie LarssonChristian BenedictHelgi B. SchiöthNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gaia Olivo Wei Zhou Magnus Sundbom Christina Zhukovsky Pleunie Hogenkamp Lamia Nikontovic Julia Stark Lyle Wiemerslage Elna-Marie Larsson Christian Benedict Helgi B. Schiöth Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study
description	Abstract Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up is yet to be assessed. We investigated changes in connectivity in 16 severely obese women one month before, one month after and one year after Roux-en-Y gastric bypass surgery (RYGB). 12 lean controls were also enrolled. Resting-state fMRI was acquired for all participants following an overnight fast and after a 260 kcal load. Connectivity between regions involved in food-related saliency attribution and reward-driven eating behavior was stronger in presurgery patients compared to controls, but progressively weakened after follow-up. At one year, changes in networks related to cognitive control over eating and bodily perception also occurred. Connectivity between regions involved in emotional control and social cognition had a temporary reduction early after treatment but had increased again after one year of follow-up. Furthermore, we could predict the BMI loss by presurgery connectivity in areas linked to emotional control and social interaction. RYGBP seems to reshape brain functional connectivity, early affecting cognitive control over eating, and these changes could be an important part of the therapeutic effect of bariatric surgery.
format	article
author	Gaia Olivo Wei Zhou Magnus Sundbom Christina Zhukovsky Pleunie Hogenkamp Lamia Nikontovic Julia Stark Lyle Wiemerslage Elna-Marie Larsson Christian Benedict Helgi B. Schiöth
author_facet	Gaia Olivo Wei Zhou Magnus Sundbom Christina Zhukovsky Pleunie Hogenkamp Lamia Nikontovic Julia Stark Lyle Wiemerslage Elna-Marie Larsson Christian Benedict Helgi B. Schiöth
author_sort	Gaia Olivo
title	Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study
title_short	Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study
title_full	Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study
title_fullStr	Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study
title_full_unstemmed	Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study
title_sort	resting-state brain connectivity changes in obese women after roux-en-y gastric bypass surgery: a longitudinal study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9d308f03b1064febbf339dec0d887bd3
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Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study

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