The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

Yahua Wang, Xue Ying, Haolun Xu, Helu Yan, Xia Li, Hui Tang Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People’s Republic of China Abstract: Glioblastoma is a kind of malignant glio...

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Autores principales: Wang YH, Ying X, Xu HL, Yan HL, Li X, Tang H
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
C6 glioblastoma stem cells
Apoptosis
Blood-brain-barrier
Curcumin liposomes
Brain glioma-bearing rats;
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/9d30acbccd434ec3bc1a1a98ada0c267
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spelling oai:doaj.org-article:9d30acbccd434ec3bc1a1a98ada0c2672021-12-02T04:05:35ZThe functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals1178-2013https://doaj.org/article/9d30acbccd434ec3bc1a1a98ada0c2672017-02-01T00:00:00Zhttps://www.dovepress.com/the-functional-curcumin-liposomes-induce-apoptosis-in-c6-glioblastoma--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yahua Wang, Xue Ying, Haolun Xu, Helu Yan, Xia Li, Hui Tang Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People’s Republic of China Abstract: Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor drug transportation across the blood–brain barrier and the existence of glioma stem cells. We prepared a new kind of targeted liposomes in order to improve the drug delivery system onto the glioma cells and induce the apoptosis of glioma stem cells afterward. In this experiment, curcumin was chosen to kill gliomas, while quinacrine was used to induce apoptosis of the glioma stem cells. Also, p-aminophenyl-α-d-mannopyranoside could facilitate the transport of liposomes across the blood–brain barrier and finally target the brain glioma cells. The cell experiments in vitro indicated that the targeted liposomes could significantly improve the antitumor effects of the drugs, while enhancing the uptake effects, apoptosis effects, and endocytic effects of C6 glioma cells and C6 glioma stem cells. Given the animal experiments in vivo, we discovered that the targeted liposomes could obviously increase the survival period of brain glioma-bearing mice and inhibit the growth of gliomas. In summary, curcumin and quinacrine liposomes modified with p-aminophenyl-α-d-mannopyranoside is a potential preparation to treat brain glioma cells and brain glioma stem cells. Keywords: C6 glioblastoma stem cells, apoptosis, blood–brain barrier, curcumin liposomes, brain glioma-bearing ratsWang YHYing XXu HLYan HLLi XTang HDove Medical PressarticleC6 glioblastoma stem cellsApoptosisBlood-brain-barrierCurcumin liposomesBrain glioma-bearing rats;Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1369-1384 (2017)
institution DOAJ
collection DOAJ
language EN
topic C6 glioblastoma stem cells
Apoptosis
Blood-brain-barrier
Curcumin liposomes
Brain glioma-bearing rats;
Medicine (General)
R5-920
spellingShingle C6 glioblastoma stem cells
Apoptosis
Blood-brain-barrier
Curcumin liposomes
Brain glioma-bearing rats;
Medicine (General)
R5-920
Wang YH
Ying X
Xu HL
Yan HL
Li X
Tang H
The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
description Yahua Wang, Xue Ying, Haolun Xu, Helu Yan, Xia Li, Hui Tang Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People’s Republic of China Abstract: Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor drug transportation across the blood–brain barrier and the existence of glioma stem cells. We prepared a new kind of targeted liposomes in order to improve the drug delivery system onto the glioma cells and induce the apoptosis of glioma stem cells afterward. In this experiment, curcumin was chosen to kill gliomas, while quinacrine was used to induce apoptosis of the glioma stem cells. Also, p-aminophenyl-α-d-mannopyranoside could facilitate the transport of liposomes across the blood–brain barrier and finally target the brain glioma cells. The cell experiments in vitro indicated that the targeted liposomes could significantly improve the antitumor effects of the drugs, while enhancing the uptake effects, apoptosis effects, and endocytic effects of C6 glioma cells and C6 glioma stem cells. Given the animal experiments in vivo, we discovered that the targeted liposomes could obviously increase the survival period of brain glioma-bearing mice and inhibit the growth of gliomas. In summary, curcumin and quinacrine liposomes modified with p-aminophenyl-α-d-mannopyranoside is a potential preparation to treat brain glioma cells and brain glioma stem cells. Keywords: C6 glioblastoma stem cells, apoptosis, blood–brain barrier, curcumin liposomes, brain glioma-bearing rats
format article
author Wang YH
Ying X
Xu HL
Yan HL
Li X
Tang H
author_facet Wang YH
Ying X
Xu HL
Yan HL
Li X
Tang H
author_sort Wang YH
title The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
title_short The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
title_full The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
title_fullStr The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
title_full_unstemmed The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
title_sort functional curcumin liposomes induce apoptosis in c6 glioblastoma cells and c6 glioblastoma stem cells in vitro and in animals
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/9d30acbccd434ec3bc1a1a98ada0c267
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