IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment

Patients with IgA vasculitis (IgAV), an immune complex-mediated disease, may exhibit kidney involvement—IgAV with nephritis (IgAVN). The kidney-biopsy histopathologic features of IgAVN are similar to those of IgA nephropathy, but little is known about histopathologic disease severity based on the in...

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Autores principales:	Lingyun Lai, Shaojun Liu, Maria Azrad, Stacy Hall, Chuanming Hao, Jan Novak, Bruce A. Julian, Lea Novak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	IgA vasculitis nephritis kidney biopsy Medicine R
Acceso en línea:	https://doaj.org/article/9d32ab45c6d34081a88d7f75495a75cb
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spelling	oai:doaj.org-article:9d32ab45c6d34081a88d7f75495a75cb2021-11-11T17:30:59ZIgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment10.3390/jcm102148512077-0383https://doaj.org/article/9d32ab45c6d34081a88d7f75495a75cb2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4851https://doaj.org/toc/2077-0383Patients with IgA vasculitis (IgAV), an immune complex-mediated disease, may exhibit kidney involvement—IgAV with nephritis (IgAVN). The kidney-biopsy histopathologic features of IgAVN are similar to those of IgA nephropathy, but little is known about histopathologic disease severity based on the interval between purpura onset and diagnostic kidney biopsy. We assessed kidney histopathology and clinical and laboratory data in a cohort of adult patients with IgAVN (n = 110). The cases were grouped based on the interval between the onset of purpura and kidney biopsy: Group 1 (G1, <1 month, n = 14), Group 2 (G2, 1–6 months, n = 58), and Group 3 (G3, >6 months, n = 38). Glomerular leukocytes were more common in G1 than in the other groups (<i>p</i> = 0.0008). The proportion of neutrophils among peripheral-blood leukocytes was the highest in the patients biopsied within a month after onset of purpura (G1: 71 ± 8%). In the patients with an interval >6 months, the neutrophil proportion was lower, 60%. Moreover, the glomerular mesangial proliferation score correlated with the serum total IgA concentration (<i>p</i> = 0.0056). In conclusion, IgAVN patients biopsied <1 month from purpura onset showed an elevated percentage of blood neutrophils and glomerular leukocytes, consistent with an acute-onset inflammatory reaction. In all IgAVN patients, the mesangial proliferation score correlated with the serum IgA level.Lingyun LaiShaojun LiuMaria AzradStacy HallChuanming HaoJan NovakBruce A. JulianLea NovakMDPI AGarticleIgA vasculitisnephritiskidney biopsyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4851, p 4851 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IgA vasculitis nephritis kidney biopsy Medicine R
spellingShingle	IgA vasculitis nephritis kidney biopsy Medicine R Lingyun Lai Shaojun Liu Maria Azrad Stacy Hall Chuanming Hao Jan Novak Bruce A. Julian Lea Novak IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment
description	Patients with IgA vasculitis (IgAV), an immune complex-mediated disease, may exhibit kidney involvement—IgAV with nephritis (IgAVN). The kidney-biopsy histopathologic features of IgAVN are similar to those of IgA nephropathy, but little is known about histopathologic disease severity based on the interval between purpura onset and diagnostic kidney biopsy. We assessed kidney histopathology and clinical and laboratory data in a cohort of adult patients with IgAVN (n = 110). The cases were grouped based on the interval between the onset of purpura and kidney biopsy: Group 1 (G1, <1 month, n = 14), Group 2 (G2, 1–6 months, n = 58), and Group 3 (G3, >6 months, n = 38). Glomerular leukocytes were more common in G1 than in the other groups (<i>p</i> = 0.0008). The proportion of neutrophils among peripheral-blood leukocytes was the highest in the patients biopsied within a month after onset of purpura (G1: 71 ± 8%). In the patients with an interval >6 months, the neutrophil proportion was lower, 60%. Moreover, the glomerular mesangial proliferation score correlated with the serum total IgA concentration (<i>p</i> = 0.0056). In conclusion, IgAVN patients biopsied <1 month from purpura onset showed an elevated percentage of blood neutrophils and glomerular leukocytes, consistent with an acute-onset inflammatory reaction. In all IgAVN patients, the mesangial proliferation score correlated with the serum IgA level.
format	article
author	Lingyun Lai Shaojun Liu Maria Azrad Stacy Hall Chuanming Hao Jan Novak Bruce A. Julian Lea Novak
author_facet	Lingyun Lai Shaojun Liu Maria Azrad Stacy Hall Chuanming Hao Jan Novak Bruce A. Julian Lea Novak
author_sort	Lingyun Lai
title	IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment
title_short	IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment
title_full	IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment
title_fullStr	IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment
title_full_unstemmed	IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment
title_sort	iga vasculitis with nephritis in adults: histological and clinical assessment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9d32ab45c6d34081a88d7f75495a75cb
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IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment

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