Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

EPO treatment improves cognition, but underlying mechanisms were unknown. Here the authors describe a regulatory loop in which brain networks challenged by cognitive tasks drift into functional hypoxia that drives—via neuronal EPO synthesis—neurodifferentiation and dendritic spine formation.

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Autores principales:	Debia Wakhloo, Franziska Scharkowski, Yasmina Curto, Umer Javed Butt, Vikas Bansal, Agnes A. Steixner-Kumar, Liane Wüstefeld, Ashish Rajput, Sahab Arinrad, Matthias R. Zillmann, Anna Seelbach, Imam Hassouna, Katharina Schneider, Abdul Qadir Ibrahim, Hauke B. Werner, Henrik Martens, Kamilla Miskowiak, Sonja M. Wojcik, Stefan Bonn, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d32af3f067e4d66a0725b72c12bd117
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spelling	oai:doaj.org-article:9d32af3f067e4d66a0725b72c12bd1172021-12-02T16:56:31ZFunctional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin10.1038/s41467-020-15041-12041-1723https://doaj.org/article/9d32af3f067e4d66a0725b72c12bd1172020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15041-1https://doaj.org/toc/2041-1723EPO treatment improves cognition, but underlying mechanisms were unknown. Here the authors describe a regulatory loop in which brain networks challenged by cognitive tasks drift into functional hypoxia that drives—via neuronal EPO synthesis—neurodifferentiation and dendritic spine formation.Debia WakhlooFranziska ScharkowskiYasmina CurtoUmer Javed ButtVikas BansalAgnes A. Steixner-KumarLiane WüstefeldAshish RajputSahab ArinradMatthias R. ZillmannAnna SeelbachImam HassounaKatharina SchneiderAbdul Qadir IbrahimHauke B. WernerHenrik MartensKamilla MiskowiakSonja M. WojcikStefan BonnJuan NacherKlaus-Armin NaveHannelore EhrenreichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Debia Wakhloo Franziska Scharkowski Yasmina Curto Umer Javed Butt Vikas Bansal Agnes A. Steixner-Kumar Liane Wüstefeld Ashish Rajput Sahab Arinrad Matthias R. Zillmann Anna Seelbach Imam Hassouna Katharina Schneider Abdul Qadir Ibrahim Hauke B. Werner Henrik Martens Kamilla Miskowiak Sonja M. Wojcik Stefan Bonn Juan Nacher Klaus-Armin Nave Hannelore Ehrenreich Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
description	EPO treatment improves cognition, but underlying mechanisms were unknown. Here the authors describe a regulatory loop in which brain networks challenged by cognitive tasks drift into functional hypoxia that drives—via neuronal EPO synthesis—neurodifferentiation and dendritic spine formation.
format	article
author	Debia Wakhloo Franziska Scharkowski Yasmina Curto Umer Javed Butt Vikas Bansal Agnes A. Steixner-Kumar Liane Wüstefeld Ashish Rajput Sahab Arinrad Matthias R. Zillmann Anna Seelbach Imam Hassouna Katharina Schneider Abdul Qadir Ibrahim Hauke B. Werner Henrik Martens Kamilla Miskowiak Sonja M. Wojcik Stefan Bonn Juan Nacher Klaus-Armin Nave Hannelore Ehrenreich
author_facet	Debia Wakhloo Franziska Scharkowski Yasmina Curto Umer Javed Butt Vikas Bansal Agnes A. Steixner-Kumar Liane Wüstefeld Ashish Rajput Sahab Arinrad Matthias R. Zillmann Anna Seelbach Imam Hassouna Katharina Schneider Abdul Qadir Ibrahim Hauke B. Werner Henrik Martens Kamilla Miskowiak Sonja M. Wojcik Stefan Bonn Juan Nacher Klaus-Armin Nave Hannelore Ehrenreich
author_sort	Debia Wakhloo
title	Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
title_short	Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
title_full	Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
title_fullStr	Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
title_full_unstemmed	Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
title_sort	functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9d32af3f067e4d66a0725b72c12bd117
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Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

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