Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review

Despite the benefits achieved by the widespread availability of modern antiretroviral therapy (ART), HIV RNA integration into the host cell genome is responsible for the creation of latent HIV reservoirs, and represents a significant impediment to completely eliminating HIV infection in a patient vi...

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Autores principales:	Silvere D. Zaongo, Feng Sun, Yaokai Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	HIV-1-specific antibody marker HIV-1 DNA HIV reservoir Level Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9d334662ac0f46dfac3c4cf43b82a19b
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spelling	oai:doaj.org-article:9d334662ac0f46dfac3c4cf43b82a19b2021-11-11T08:36:48ZAre HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review1664-322410.3389/fimmu.2021.786341https://doaj.org/article/9d334662ac0f46dfac3c4cf43b82a19b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.786341/fullhttps://doaj.org/toc/1664-3224Despite the benefits achieved by the widespread availability of modern antiretroviral therapy (ART), HIV RNA integration into the host cell genome is responsible for the creation of latent HIV reservoirs, and represents a significant impediment to completely eliminating HIV infection in a patient via modern ART alone. Several methods to measure HIV reservoir size exist; however, simpler, cheaper, and faster tools are required in the quest for total HIV cure. Over the past few years, measurement of HIV-specific antibodies has evolved into a promising option for measuring HIV reservoir size, as they can be measured via simple, well-known techniques such as the western blot and enzyme-linked immunosorbent assay (ELISA). In this article, we re-visit the dynamic evolution of HIV-1-specific antibodies and the factors that may influence their levels in the circulation of HIV-positive individuals. Then, we describe the currently-known relationship between HIV-1-specific antibodies and HIV reservoir size based on study of data from contemporary literature published during the past 5 years. We conclude by highlighting current trends, and discussing the individual HIV-specific antibody that is likely to be the most reliable antibody for potential future utilization for quantification of HIV reservoir size.Silvere D. ZaongoFeng SunYaokai ChenFrontiers Media S.A.articleHIV-1-specific antibodymarkerHIV-1 DNAHIV reservoirLevelImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV-1-specific antibody marker HIV-1 DNA HIV reservoir Level Immunologic diseases. Allergy RC581-607
spellingShingle	HIV-1-specific antibody marker HIV-1 DNA HIV reservoir Level Immunologic diseases. Allergy RC581-607 Silvere D. Zaongo Feng Sun Yaokai Chen Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review
description	Despite the benefits achieved by the widespread availability of modern antiretroviral therapy (ART), HIV RNA integration into the host cell genome is responsible for the creation of latent HIV reservoirs, and represents a significant impediment to completely eliminating HIV infection in a patient via modern ART alone. Several methods to measure HIV reservoir size exist; however, simpler, cheaper, and faster tools are required in the quest for total HIV cure. Over the past few years, measurement of HIV-specific antibodies has evolved into a promising option for measuring HIV reservoir size, as they can be measured via simple, well-known techniques such as the western blot and enzyme-linked immunosorbent assay (ELISA). In this article, we re-visit the dynamic evolution of HIV-1-specific antibodies and the factors that may influence their levels in the circulation of HIV-positive individuals. Then, we describe the currently-known relationship between HIV-1-specific antibodies and HIV reservoir size based on study of data from contemporary literature published during the past 5 years. We conclude by highlighting current trends, and discussing the individual HIV-specific antibody that is likely to be the most reliable antibody for potential future utilization for quantification of HIV reservoir size.
format	article
author	Silvere D. Zaongo Feng Sun Yaokai Chen
author_facet	Silvere D. Zaongo Feng Sun Yaokai Chen
author_sort	Silvere D. Zaongo
title	Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review
title_short	Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review
title_full	Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review
title_fullStr	Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review
title_full_unstemmed	Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review
title_sort	are hiv-1-specific antibody levels potentially useful laboratory markers to estimate hiv reservoir size? a review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9d334662ac0f46dfac3c4cf43b82a19b
work_keys_str_mv	AT silveredzaongo arehiv1specificantibodylevelspotentiallyusefullaboratorymarkerstoestimatehivreservoirsizeareview AT fengsun arehiv1specificantibodylevelspotentiallyusefullaboratorymarkerstoestimatehivreservoirsizeareview AT yaokaichen arehiv1specificantibodylevelspotentiallyusefullaboratorymarkerstoestimatehivreservoirsizeareview
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Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review

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