Medium-thickness-dependent proton dosimetry for radiobiological experiments

Abstract A calibration method was proposed in the present work to determine the medium-thickness-dependent proton doses absorbed in cellular components (i.e., cellular cytoplasm and nucleus) in radiobiological experiments. Consideration of the dependency on medium thickness was crucial as the linear...

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Autores principales:	Mehrdad Shahmohammadi Beni, Dragana Krstic, Dragoslav Nikezic, Kwan Ngok Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d33fe6b9fe5470cac8b48bdc98eea47
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spelling	oai:doaj.org-article:9d33fe6b9fe5470cac8b48bdc98eea472021-12-02T15:08:30ZMedium-thickness-dependent proton dosimetry for radiobiological experiments10.1038/s41598-019-48100-92045-2322https://doaj.org/article/9d33fe6b9fe5470cac8b48bdc98eea472019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48100-9https://doaj.org/toc/2045-2322Abstract A calibration method was proposed in the present work to determine the medium-thickness-dependent proton doses absorbed in cellular components (i.e., cellular cytoplasm and nucleus) in radiobiological experiments. Consideration of the dependency on medium thickness was crucial as the linear energy transfer (LET) of protons could rise to a sharp peak (known as the Bragg peak) towards the end of their ranges. Relationships between the calibration coefficient R vs medium-layer thickness were obtained for incident proton energies of 10, 15, 20, 25, 30 and 35 MeV, and for various medium thicknesses up to 5000 μm, where R was defined as the ratio D A /D E , D A was the absorbed proton dose in cellular components, and D E was the absorbed proton dose in a separate radiation detector. In the present work, D A and D E were determined using the MCNPX (Monte Carlo N-Particle eXtended) code version 2.4.0. For lower incident proton energies (i.e., 10, 15 and 20 MeV), formation of Bragg-peak-like features were noticed in their R-vs-medium-layer-thickness relationships, and large R values of >7 and >6 were obtained for cytoplasm and nucleus of cells, respectively, which highlighted the importance of careful consideration of the medium thickness in radiobiological experiments.Mehrdad Shahmohammadi BeniDragana KrsticDragoslav NikezicKwan Ngok YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mehrdad Shahmohammadi Beni Dragana Krstic Dragoslav Nikezic Kwan Ngok Yu Medium-thickness-dependent proton dosimetry for radiobiological experiments
description	Abstract A calibration method was proposed in the present work to determine the medium-thickness-dependent proton doses absorbed in cellular components (i.e., cellular cytoplasm and nucleus) in radiobiological experiments. Consideration of the dependency on medium thickness was crucial as the linear energy transfer (LET) of protons could rise to a sharp peak (known as the Bragg peak) towards the end of their ranges. Relationships between the calibration coefficient R vs medium-layer thickness were obtained for incident proton energies of 10, 15, 20, 25, 30 and 35 MeV, and for various medium thicknesses up to 5000 μm, where R was defined as the ratio D A /D E , D A was the absorbed proton dose in cellular components, and D E was the absorbed proton dose in a separate radiation detector. In the present work, D A and D E were determined using the MCNPX (Monte Carlo N-Particle eXtended) code version 2.4.0. For lower incident proton energies (i.e., 10, 15 and 20 MeV), formation of Bragg-peak-like features were noticed in their R-vs-medium-layer-thickness relationships, and large R values of >7 and >6 were obtained for cytoplasm and nucleus of cells, respectively, which highlighted the importance of careful consideration of the medium thickness in radiobiological experiments.
format	article
author	Mehrdad Shahmohammadi Beni Dragana Krstic Dragoslav Nikezic Kwan Ngok Yu
author_facet	Mehrdad Shahmohammadi Beni Dragana Krstic Dragoslav Nikezic Kwan Ngok Yu
author_sort	Mehrdad Shahmohammadi Beni
title	Medium-thickness-dependent proton dosimetry for radiobiological experiments
title_short	Medium-thickness-dependent proton dosimetry for radiobiological experiments
title_full	Medium-thickness-dependent proton dosimetry for radiobiological experiments
title_fullStr	Medium-thickness-dependent proton dosimetry for radiobiological experiments
title_full_unstemmed	Medium-thickness-dependent proton dosimetry for radiobiological experiments
title_sort	medium-thickness-dependent proton dosimetry for radiobiological experiments
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9d33fe6b9fe5470cac8b48bdc98eea47
work_keys_str_mv	AT mehrdadshahmohammadibeni mediumthicknessdependentprotondosimetryforradiobiologicalexperiments AT draganakrstic mediumthicknessdependentprotondosimetryforradiobiologicalexperiments AT dragoslavnikezic mediumthicknessdependentprotondosimetryforradiobiologicalexperiments AT kwanngokyu mediumthicknessdependentprotondosimetryforradiobiologicalexperiments
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Medium-thickness-dependent proton dosimetry for radiobiological experiments

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