Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications

Takeo Fukuchi, Kimiko Wakai, Kieko Suda, Tomoko Nakatsue, Hideko Sawada, Hiroaki Hara, Jun Ueda, Takayuki Tanaka, Akiko Yamada, Haruki AbeDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JapanPurpose: To evaluate the incidence...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takeo Fukuchi, Kimiko Wakai, Kieko Suda, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9d366bf2114b4c75a3f11d0f5d76692e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9d366bf2114b4c75a3f11d0f5d76692e
record_format	dspace
spelling	oai:doaj.org-article:9d366bf2114b4c75a3f11d0f5d76692e2021-12-02T06:31:38ZIncidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications1177-54671177-5483https://doaj.org/article/9d366bf2114b4c75a3f11d0f5d76692e2010-04-01T00:00:00Zhttp://www.dovepress.com/incidence-severity-and-factors-related-to-drug-induced-keratoepithelio-a4277https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Takeo Fukuchi, Kimiko Wakai, Kieko Suda, Tomoko Nakatsue, Hideko Sawada, Hiroaki Hara, Jun Ueda, Takayuki Tanaka, Akiko Yamada, Haruki AbeDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JapanPurpose: To evaluate the incidence, severity, and factors related to drug-induced keratoepitheliopathy in eyes using antiglaucoma eye drops.Patients and methods: In a cross-sectional study, 749 eyes from 427 patients who had used one or more antiglaucoma eye drops were examined at Niigata University Medical and Dental Hospital or related facilities. The incidence and severity of superficial punctate keratitis (SPK), patient gender and age, type of glaucoma, and type of eye drops were recorded. SPK was graded according to the AD (A, area; D, density) classification. The severity score (SS) was calculated from A &times; D.Results: SPK was observed in 382 (51.0%) of 749 eyes that had received any type of antiglaucoma eye drops. While 254 eyes (33.9%) were classified as A1D1 (SS 1), 34 eyes (4.6%) had severe SPK with SS 4 or more. The number of eye drops and the total dosing frequency per day were significantly greater in SPK-positive eyes than in eyes without SPK. The number of eye drops was proportional to the frequency and severity of SPK. Among eyes that were treated with three or more eye drops, SPK was more severe and more frequent in older patients (&ge;71 years). In addition, a considerable difference was detected for each type of glaucoma.Conclusion: Drug-induced keratoepitheliopathy is often observed in eyes that have received recent antiglaucoma eye drops. The number of eye drops, the total dose frequency per day, patient age, and type of glaucoma may affect this condition. We have to consider not only the effects on intraocular pressure but also the incidence and severity of drug-induced keratoepitheliopathy as a frequent side effect of glaucoma medications.Keywords: glaucoma, medications, eye drops, keratoepitheliopathy, AD classification Takeo FukuchiKimiko WakaiKieko Sudaet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 203-209 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Takeo Fukuchi Kimiko Wakai Kieko Suda et al Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications
description	Takeo Fukuchi, Kimiko Wakai, Kieko Suda, Tomoko Nakatsue, Hideko Sawada, Hiroaki Hara, Jun Ueda, Takayuki Tanaka, Akiko Yamada, Haruki AbeDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JapanPurpose: To evaluate the incidence, severity, and factors related to drug-induced keratoepitheliopathy in eyes using antiglaucoma eye drops.Patients and methods: In a cross-sectional study, 749 eyes from 427 patients who had used one or more antiglaucoma eye drops were examined at Niigata University Medical and Dental Hospital or related facilities. The incidence and severity of superficial punctate keratitis (SPK), patient gender and age, type of glaucoma, and type of eye drops were recorded. SPK was graded according to the AD (A, area; D, density) classification. The severity score (SS) was calculated from A &times; D.Results: SPK was observed in 382 (51.0%) of 749 eyes that had received any type of antiglaucoma eye drops. While 254 eyes (33.9%) were classified as A1D1 (SS 1), 34 eyes (4.6%) had severe SPK with SS 4 or more. The number of eye drops and the total dosing frequency per day were significantly greater in SPK-positive eyes than in eyes without SPK. The number of eye drops was proportional to the frequency and severity of SPK. Among eyes that were treated with three or more eye drops, SPK was more severe and more frequent in older patients (&ge;71 years). In addition, a considerable difference was detected for each type of glaucoma.Conclusion: Drug-induced keratoepitheliopathy is often observed in eyes that have received recent antiglaucoma eye drops. The number of eye drops, the total dose frequency per day, patient age, and type of glaucoma may affect this condition. We have to consider not only the effects on intraocular pressure but also the incidence and severity of drug-induced keratoepitheliopathy as a frequent side effect of glaucoma medications.Keywords: glaucoma, medications, eye drops, keratoepitheliopathy, AD classification
format	article
author	Takeo Fukuchi Kimiko Wakai Kieko Suda et al
author_facet	Takeo Fukuchi Kimiko Wakai Kieko Suda et al
author_sort	Takeo Fukuchi
title	Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications
title_short	Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications
title_full	Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications
title_fullStr	Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications
title_full_unstemmed	Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications
title_sort	incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/9d366bf2114b4c75a3f11d0f5d76692e
work_keys_str_mv	AT takeofukuchi incidenceseverityandfactorsrelatedtodruginducedkeratoepitheliopathywithglaucomamedications AT kimikowakai incidenceseverityandfactorsrelatedtodruginducedkeratoepitheliopathywithglaucomamedications AT kiekosuda incidenceseverityandfactorsrelatedtodruginducedkeratoepitheliopathywithglaucomamedications AT etal incidenceseverityandfactorsrelatedtodruginducedkeratoepitheliopathywithglaucomamedications
_version_	1718399891415236608

Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications

Ejemplares similares