Acute microglia ablation induces neurodegeneration in the somatosensory system

Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory comp...

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Autores principales:	Stephen J. Rubino, Lior Mayo, Isabella Wimmer, Victoria Siedler, Florian Brunner, Simon Hametner, Asaf Madi, Amanda Lanser, Thais Moreira, Dustin Donnelly, Laura Cox, Rafael Machado Rezende, Oleg Butovsky, Hans Lassmann, Howard L. Weiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d3a63c0ded44732a54cfe43f20342b8
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spelling	oai:doaj.org-article:9d3a63c0ded44732a54cfe43f20342b82021-12-02T17:31:15ZAcute microglia ablation induces neurodegeneration in the somatosensory system10.1038/s41467-018-05929-42041-1723https://doaj.org/article/9d3a63c0ded44732a54cfe43f20342b82018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05929-4https://doaj.org/toc/2041-1723Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory components that may contribute.Stephen J. RubinoLior MayoIsabella WimmerVictoria SiedlerFlorian BrunnerSimon HametnerAsaf MadiAmanda LanserThais MoreiraDustin DonnellyLaura CoxRafael Machado RezendeOleg ButovskyHans LassmannHoward L. WeinerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen J. Rubino Lior Mayo Isabella Wimmer Victoria Siedler Florian Brunner Simon Hametner Asaf Madi Amanda Lanser Thais Moreira Dustin Donnelly Laura Cox Rafael Machado Rezende Oleg Butovsky Hans Lassmann Howard L. Weiner Acute microglia ablation induces neurodegeneration in the somatosensory system
description	Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory components that may contribute.
format	article
author	Stephen J. Rubino Lior Mayo Isabella Wimmer Victoria Siedler Florian Brunner Simon Hametner Asaf Madi Amanda Lanser Thais Moreira Dustin Donnelly Laura Cox Rafael Machado Rezende Oleg Butovsky Hans Lassmann Howard L. Weiner
author_facet	Stephen J. Rubino Lior Mayo Isabella Wimmer Victoria Siedler Florian Brunner Simon Hametner Asaf Madi Amanda Lanser Thais Moreira Dustin Donnelly Laura Cox Rafael Machado Rezende Oleg Butovsky Hans Lassmann Howard L. Weiner
author_sort	Stephen J. Rubino
title	Acute microglia ablation induces neurodegeneration in the somatosensory system
title_short	Acute microglia ablation induces neurodegeneration in the somatosensory system
title_full	Acute microglia ablation induces neurodegeneration in the somatosensory system
title_fullStr	Acute microglia ablation induces neurodegeneration in the somatosensory system
title_full_unstemmed	Acute microglia ablation induces neurodegeneration in the somatosensory system
title_sort	acute microglia ablation induces neurodegeneration in the somatosensory system
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9d3a63c0ded44732a54cfe43f20342b8
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Acute microglia ablation induces neurodegeneration in the somatosensory system

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