Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy

Background and purpose: Whole bladder radiotherapy is challenging due to inter- and intrafraction size and shape changes. To account for these changes, currently a Library of Plans (LoP) technique is often applied, but daily adaptive radiotherapy is also increasingly becoming available. The aim of t...

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Autores principales:	Duncan den Boer, Mariska D. den Hartogh, Alexis N.T.J. Kotte, Jochem R.N. van der Voort van Zyp, Juus L. Noteboom, Gijsbert H. Bol, Thomas Willigenburg, Anita M. Werensteijn-Honingh, Ina M. Jürgenliemk-Schulz, Astrid L.H.M.W. van Lier, Petra S. Kroon
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bladder cancer MR-guided radiotherapy Daily online adaptive radiotherapy Library of Plans Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9d3b895f59684e58a8ba3f828146316f
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spelling	oai:doaj.org-article:9d3b895f59684e58a8ba3f828146316f2021-11-22T04:27:33ZComparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy2405-631610.1016/j.phro.2021.11.002https://doaj.org/article/9d3b895f59684e58a8ba3f828146316f2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S240563162100066Xhttps://doaj.org/toc/2405-6316Background and purpose: Whole bladder radiotherapy is challenging due to inter- and intrafraction size and shape changes. To account for these changes, currently a Library of Plans (LoP) technique is often applied, but daily adaptive radiotherapy is also increasingly becoming available. The aim of this study was to compare LoP with two magnetic resonance imaging guided radiotherapy (MRgRT) strategies by comparing target coverage and volume of healthy tissue inside the planning target volume (PTV) for whole bladder treatments. Methods and materials: Data from 25 MRgRT lymph node oligometastases treatments (125 fractions) were used, with three MRI scans acquired at each fraction at 0, 15 and 30 min. Bladders were delineated and used to evaluate three strategies: 1) LoP with two plans for a 15 min fraction, 2) MRgRT15min for a 15 min fraction and 3) MRgRT30min for a 30 min fraction. The volumes of healthy tissue inside and bladder outside the PTV were analyzed on the simulated post-treatment images. Results: MRgRT30min had 120% and 121% more healthy tissue inside the PTV than LoP and MRgRT15min. For LoP slightly more target outside the PTV was found than for MRgRT30min and MRgRT15min, with median 0% (range 0–23%) compared to 0% (0–20%) and 0% (0–10%), respectively. Conclusions: Taking into account both target coverage and volume of healthy tissue inside the PTV, MRgRT15min performed better than LoP and MRgRT30min for whole bladder treatments. A 15 min daily adaptive radiotherapy workflow is needed to potentially benefit from replanning compared to LoP.Duncan den BoerMariska D. den HartoghAlexis N.T.J. KotteJochem R.N. van der Voort van ZypJuus L. NoteboomGijsbert H. BolThomas WilligenburgAnita M. Werensteijn-HoninghIna M. Jürgenliemk-SchulzAstrid L.H.M.W. van LierPetra S. KroonElsevierarticleBladder cancerMR-guided radiotherapyDaily online adaptive radiotherapyLibrary of PlansMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENPhysics and Imaging in Radiation Oncology, Vol 20, Iss , Pp 82-87 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bladder cancer MR-guided radiotherapy Daily online adaptive radiotherapy Library of Plans Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Bladder cancer MR-guided radiotherapy Daily online adaptive radiotherapy Library of Plans Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Duncan den Boer Mariska D. den Hartogh Alexis N.T.J. Kotte Jochem R.N. van der Voort van Zyp Juus L. Noteboom Gijsbert H. Bol Thomas Willigenburg Anita M. Werensteijn-Honingh Ina M. Jürgenliemk-Schulz Astrid L.H.M.W. van Lier Petra S. Kroon Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy
description	Background and purpose: Whole bladder radiotherapy is challenging due to inter- and intrafraction size and shape changes. To account for these changes, currently a Library of Plans (LoP) technique is often applied, but daily adaptive radiotherapy is also increasingly becoming available. The aim of this study was to compare LoP with two magnetic resonance imaging guided radiotherapy (MRgRT) strategies by comparing target coverage and volume of healthy tissue inside the planning target volume (PTV) for whole bladder treatments. Methods and materials: Data from 25 MRgRT lymph node oligometastases treatments (125 fractions) were used, with three MRI scans acquired at each fraction at 0, 15 and 30 min. Bladders were delineated and used to evaluate three strategies: 1) LoP with two plans for a 15 min fraction, 2) MRgRT15min for a 15 min fraction and 3) MRgRT30min for a 30 min fraction. The volumes of healthy tissue inside and bladder outside the PTV were analyzed on the simulated post-treatment images. Results: MRgRT30min had 120% and 121% more healthy tissue inside the PTV than LoP and MRgRT15min. For LoP slightly more target outside the PTV was found than for MRgRT30min and MRgRT15min, with median 0% (range 0–23%) compared to 0% (0–20%) and 0% (0–10%), respectively. Conclusions: Taking into account both target coverage and volume of healthy tissue inside the PTV, MRgRT15min performed better than LoP and MRgRT30min for whole bladder treatments. A 15 min daily adaptive radiotherapy workflow is needed to potentially benefit from replanning compared to LoP.
format	article
author	Duncan den Boer Mariska D. den Hartogh Alexis N.T.J. Kotte Jochem R.N. van der Voort van Zyp Juus L. Noteboom Gijsbert H. Bol Thomas Willigenburg Anita M. Werensteijn-Honingh Ina M. Jürgenliemk-Schulz Astrid L.H.M.W. van Lier Petra S. Kroon
author_facet	Duncan den Boer Mariska D. den Hartogh Alexis N.T.J. Kotte Jochem R.N. van der Voort van Zyp Juus L. Noteboom Gijsbert H. Bol Thomas Willigenburg Anita M. Werensteijn-Honingh Ina M. Jürgenliemk-Schulz Astrid L.H.M.W. van Lier Petra S. Kroon
author_sort	Duncan den Boer
title	Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy
title_short	Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy
title_full	Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy
title_fullStr	Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy
title_full_unstemmed	Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy
title_sort	comparison of library of plans with two daily adaptive strategies for whole bladder radiotherapy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9d3b895f59684e58a8ba3f828146316f
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Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy

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