Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutation
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Nature Portfolio
2020
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oai:doaj.org-article:9d3d9f430d2e481298f1f134583ff8b62021-12-02T17:33:12ZExtensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D10.1038/s41467-019-14224-92041-1723https://doaj.org/article/9d3d9f430d2e481298f1f134583ff8b62020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14224-9https://doaj.org/toc/2041-1723Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutationSusan A. KennedyMohamed-Ali JarbouiSriganesh SrihariCinzia RasoKenneth BryanLayal DernaykaTheodosia CharitouManuel Bernal-LlinaresCarlos Herrera-MontavezAleksandar KrsticDavid MatallanasMax KotlyarIgor JurisicaJasna CurakVictoria WongIgor StagljarThierry LeBihanLisa ImriePriyanka PillaiMiriam A. LynnErik FasteriusCristina Al-Khalili SzigyartoJames BreenChristina KielLuis SerranoNora RauchOleksii RukhlenkoBoris N. KholodenkoLuis F. Iglesias-MartinezColm J. RyanRuth PilkingtonPatrizia CammareriOwen SansomSteven ShaveManfred AuerNicola HornFranziska KloseMarius UeffingKarsten BoldtDavid J. LynnWalter KolchNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Susan A. Kennedy Mohamed-Ali Jarboui Sriganesh Srihari Cinzia Raso Kenneth Bryan Layal Dernayka Theodosia Charitou Manuel Bernal-Llinares Carlos Herrera-Montavez Aleksandar Krstic David Matallanas Max Kotlyar Igor Jurisica Jasna Curak Victoria Wong Igor Stagljar Thierry LeBihan Lisa Imrie Priyanka Pillai Miriam A. Lynn Erik Fasterius Cristina Al-Khalili Szigyarto James Breen Christina Kiel Luis Serrano Nora Rauch Oleksii Rukhlenko Boris N. Kholodenko Luis F. Iglesias-Martinez Colm J. Ryan Ruth Pilkington Patrizia Cammareri Owen Sansom Steven Shave Manfred Auer Nicola Horn Franziska Klose Marius Ueffing Karsten Boldt David J. Lynn Walter Kolch Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D |
| description |
Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutation |
| format |
article |
| author |
Susan A. Kennedy Mohamed-Ali Jarboui Sriganesh Srihari Cinzia Raso Kenneth Bryan Layal Dernayka Theodosia Charitou Manuel Bernal-Llinares Carlos Herrera-Montavez Aleksandar Krstic David Matallanas Max Kotlyar Igor Jurisica Jasna Curak Victoria Wong Igor Stagljar Thierry LeBihan Lisa Imrie Priyanka Pillai Miriam A. Lynn Erik Fasterius Cristina Al-Khalili Szigyarto James Breen Christina Kiel Luis Serrano Nora Rauch Oleksii Rukhlenko Boris N. Kholodenko Luis F. Iglesias-Martinez Colm J. Ryan Ruth Pilkington Patrizia Cammareri Owen Sansom Steven Shave Manfred Auer Nicola Horn Franziska Klose Marius Ueffing Karsten Boldt David J. Lynn Walter Kolch |
| author_facet |
Susan A. Kennedy Mohamed-Ali Jarboui Sriganesh Srihari Cinzia Raso Kenneth Bryan Layal Dernayka Theodosia Charitou Manuel Bernal-Llinares Carlos Herrera-Montavez Aleksandar Krstic David Matallanas Max Kotlyar Igor Jurisica Jasna Curak Victoria Wong Igor Stagljar Thierry LeBihan Lisa Imrie Priyanka Pillai Miriam A. Lynn Erik Fasterius Cristina Al-Khalili Szigyarto James Breen Christina Kiel Luis Serrano Nora Rauch Oleksii Rukhlenko Boris N. Kholodenko Luis F. Iglesias-Martinez Colm J. Ryan Ruth Pilkington Patrizia Cammareri Owen Sansom Steven Shave Manfred Auer Nicola Horn Franziska Klose Marius Ueffing Karsten Boldt David J. Lynn Walter Kolch |
| author_sort |
Susan A. Kennedy |
| title |
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D |
| title_short |
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D |
| title_full |
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D |
| title_fullStr |
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D |
| title_full_unstemmed |
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D |
| title_sort |
extensive rewiring of the egfr network in colorectal cancer cells expressing transforming levels of krasg13d |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/9d3d9f430d2e481298f1f134583ff8b6 |
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1718380014468071424 |