Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution

mRNA surveillance is essential to maintain homeostasis in eukaryotes and is activated by mRNAs lacking a stop codon. Here the authors describe a high resolution cryo-EM structure of a nonstop complex that shows how arrested ribosome recognition is achieved during Dom34-mediated mRNA surveillance.

Guardado en:

Detalles Bibliográficos
Autores principales:	Tarek Hilal, Hiroshi Yamamoto, Justus Loerke, Jörg Bürger, Thorsten Mielke, Christian M.T. Spahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d3fba2dc6ee41d78b7c23117e5d18c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9d3fba2dc6ee41d78b7c23117e5d18c5
record_format	dspace
spelling	oai:doaj.org-article:9d3fba2dc6ee41d78b7c23117e5d18c52021-12-02T16:49:40ZStructural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution10.1038/ncomms135212041-1723https://doaj.org/article/9d3fba2dc6ee41d78b7c23117e5d18c52016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13521https://doaj.org/toc/2041-1723mRNA surveillance is essential to maintain homeostasis in eukaryotes and is activated by mRNAs lacking a stop codon. Here the authors describe a high resolution cryo-EM structure of a nonstop complex that shows how arrested ribosome recognition is achieved during Dom34-mediated mRNA surveillance.Tarek HilalHiroshi YamamotoJustus LoerkeJörg BürgerThorsten MielkeChristian M.T. SpahnNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tarek Hilal Hiroshi Yamamoto Justus Loerke Jörg Bürger Thorsten Mielke Christian M.T. Spahn Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution
description	mRNA surveillance is essential to maintain homeostasis in eukaryotes and is activated by mRNAs lacking a stop codon. Here the authors describe a high resolution cryo-EM structure of a nonstop complex that shows how arrested ribosome recognition is achieved during Dom34-mediated mRNA surveillance.
format	article
author	Tarek Hilal Hiroshi Yamamoto Justus Loerke Jörg Bürger Thorsten Mielke Christian M.T. Spahn
author_facet	Tarek Hilal Hiroshi Yamamoto Justus Loerke Jörg Bürger Thorsten Mielke Christian M.T. Spahn
author_sort	Tarek Hilal
title	Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution
title_short	Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution
title_full	Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution
title_fullStr	Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution
title_full_unstemmed	Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution
title_sort	structural insights into ribosomal rescue by dom34 and hbs1 at near-atomic resolution
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9d3fba2dc6ee41d78b7c23117e5d18c5
work_keys_str_mv	AT tarekhilal structuralinsightsintoribosomalrescuebydom34andhbs1atnearatomicresolution AT hiroshiyamamoto structuralinsightsintoribosomalrescuebydom34andhbs1atnearatomicresolution AT justusloerke structuralinsightsintoribosomalrescuebydom34andhbs1atnearatomicresolution AT jorgburger structuralinsightsintoribosomalrescuebydom34andhbs1atnearatomicresolution AT thorstenmielke structuralinsightsintoribosomalrescuebydom34andhbs1atnearatomicresolution AT christianmtspahn structuralinsightsintoribosomalrescuebydom34andhbs1atnearatomicresolution
_version_	1718383231304204288

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution

Ejemplares similares